Description

(R,S)-α-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic Acid-13C2,15N CAS NO 1219376-36-9 is a high-purity, stable isotope-labeled analog of AMPA, a critical compound in neuroscience research. This product is specifically designed for use as an internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy and reliability in analytical data. It is an essential reagent for pharmaceutical R&D, academic research, and contract research organizations (CROs) focused on neuropharmacology, receptor studies, and metabolomics.

Application

• Quantitative Mass Spectrometry (LC-MS/MS, GC-MS): Serves as a critical internal standard for the precise quantification of AMPA and related compounds in complex biological matrices.
• Neuropharmacology Research: Used in receptor binding assays and functional studies to investigate the glutamatergic system and excitatory neurotransmission.
• Drug Metabolism and Pharmacokinetics (DMPK): Enables accurate tracking of drug candidates and their metabolites in in vitro and in vivo studies.
• Biomarker Discovery & Validation: Facilitates the reliable measurement of endogenous AMPA levels in clinical and preclinical samples for disease research.
• Quality Control & Method Development: Employed in analytical laboratories for developing, validating, and auditing sensitive detection methods.
• Metabolomics and Proteomics: Aids in pathway analysis by providing a stable isotope-labeled reference point for glutamate receptor-related metabolites.

Basic Information

Item	Details
Product Name	(R,S)-α-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic Acid-13C2,15N
CAS No.	1219376-36-9
Molecular Formula	C513C2H815NNO4
Molecular Weight	~177.10 g/mol (for labeled form)
Synonyms	AMPA-13C2,15N; (RS)-AMPA-13C2,15N; (±)-α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-13C2,15N; 2-Amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid-13C2,15N; Stable Isotope Labeled AMPA; AMPA Internal Standard; DL-AMPA-13C2,15N
EINECS	Contact for details

Quality Control

Every batch of our (R,S)-α-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic Acid-13C2,15N is manufactured under strict quality management systems. The product undergoes rigorous analytical testing, including NMR (1H, 13C) and High-Resolution Mass Spectrometry (HRMS), to confirm isotopic enrichment, chemical purity, and structural identity. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic purity (atom % 13C and 15N), and analytical data is provided with each shipment to ensure traceability and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This compound is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (NMR)	Conforms to structure
Identification (HRMS)	Conforms to structure
Purity (HPLC)	≥98%
Isotopic Purity (13C)	≥99 atom % 13C
Isotopic Purity (15N)	≥99 atom % 15N
Chemical Purity	≥95%
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.