Description

2-(2,2,2-Trifluoroethoxy)Pyridine-3-Boronic Acid is a high-value, multifunctional boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its core value lies in enabling the precise construction of complex molecules through reliable cross-coupling reactions. This advanced intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of novel active ingredients. Its unique trifluoroethoxy-pyridine structure imparts desirable physicochemical properties to final compounds.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, especially in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used to create advanced pyridine-based herbicides, fungicides, and insecticides with enhanced efficacy and environmental profiles.
• Ligand & Catalyst Development: Employed in the design and synthesis of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Serves as a building block for organic electronic materials, such as those used in OLEDs and semiconductors.
• Chemical Biology Probes: Utilized in the creation of molecular probes and sensors for diagnostic and research applications.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	2-(2,2,2-Trifluoroethoxy)Pyridine-3-Boronic Acid
CAS No.	1218790-79-4
Molecular Formula	C7H7BF3NO3
Molecular Weight	220.94 g/mol
Synonyms	3-Pyridineboronic acid, 2-(2,2,2-trifluoroethoxy)-; 2-(Trifluoroethoxy)pyridine-3-boronic acid; (2-(2,2,2-Trifluoroethoxy)pyridin-3-yl)boronic acid; 1218790-79-4; 2-(2,2,2-Trifluoroethoxy)-3-pyridinylboronic acid; 3-Borono-2-(2,2,2-trifluoroethoxy)pyridine
EINECS	Contact for details

Quality Control

Our 2-(2,2,2-Trifluoroethoxy)Pyridine-3-Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing purity, identity, and impurity profiles. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (argon or nitrogen) to prevent degradation. For long-term storage, consider storing under an inert gas blanket in a freezer (-20°C).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.