Description

6-(Isobutylthio)Pyridine-3-Boronic Acid is a high-value organoboron building block, specifically a pyridine-thioether boronic acid derivative, essential for modern cross-coupling chemistry. Its unique structure, combining a boronic acid functionality with a sulfur-linked isobutyl group on the pyridine ring, makes it a critical reagent for constructing complex molecules in pharmaceutical and agrochemical research. This compound is primarily utilized by R&D chemists and process development scientists in the life sciences sector for creating novel active ingredients and advanced materials.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a key boronic acid coupling partner for the synthesis of biaryl and heterobiaryl structures, which are core scaffolds in many drug candidates.
• Pharmaceutical Intermediate: Used in the research and development of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors, antiviral agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Employed in creating novel herbicides, fungicides, and insecticides that require specific pyridine-thioether motifs for bioactivity.
• Ligand and Catalyst Development: Acts as a precursor for synthesizing specialized ligands used in catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Utilized in the development of organic electronic materials and functional polymers where the pyridine and boronic acid groups impart specific electronic properties.
• Chemical Biology Probes: Facilitates the synthesis of tagged molecules and probes for studying biological pathways and protein interactions.

Basic Information

Product Name	6-(Isobutylthio)Pyridine-3-Boronic Acid
CAS No.	1218790-69-2
Molecular Formula	C10H16BNO2S
Molecular Weight	225.12 g/mol
Synonyms	6-(2-Methylpropylthio)pyridine-3-boronic acid; 3-Pyridineboronic acid, 6-[(2-methylpropyl)thio]-; (6-((Isobutylthio)pyridin-3-yl)boronic acid; 6-(Isobutylsulfanyl)pyridine-3-boronic acid; Boronic acid, B-[6-[(2-methylpropyl)thio]-3-pyridinyl]-; 1218790-69-2; Pyridine-3-boronic acid, 6-(isobutylthio)-
EINECS	Contact for details

Quality Control

Every batch of 6-(Isobutylthio)Pyridine-3-Boronic Acid is produced and tested under strict quality management systems to ensure consistency and reliability for sensitive synthetic applications. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with exacting industry standards. Certificates of Analysis (COA) with detailed purity and impurity profiles are available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C in a cool, dry place. This compound is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air, moisture, or elevated temperatures should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥95% (Typical 97-99%)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.