Description

Vanillylamine-D3 Hydrochloride is a deuterium-labeled isotopologue of vanillylamine hydrochloride, a key intermediate in the synthesis of capsaicinoids and other bioactive compounds. This labeled compound is essential for creating internal standards used in high-precision analytical methods like LC-MS/MS, enabling accurate quantification and metabolic studies. It is primarily utilized by research institutions, pharmaceutical developers, and analytical laboratories focused on neuroscience, pain research, and pharmacokinetics.

Application

• Internal Standard for Mass Spectrometry: Serves as a critical deuterated internal standard for the accurate quantification of vanillylamine, capsaicin, and related vanilloids in complex biological matrices using LC-MS/MS and GC-MS.
• Pharmaceutical Research & Development: Used in the synthesis of deuterium-labeled drug candidates for pharmacokinetic (PK), pharmacodynamic (PD), and absorption, distribution, metabolism, and excretion (ADME) studies.
• Metabolic Pathway Tracing: Enables detailed investigation of the metabolic fate of vanillyl compounds in vivo through isotope tracing techniques.
• Neuroscience and Pain Research: A vital building block for synthesizing labeled analogs of capsaicin to study the TRPV1 receptor mechanism and develop novel analgesic agents.
• Analytical Method Development: Employed to validate and calibrate analytical methods for food chemistry, natural product analysis, and forensic toxicology where capsaicinoids are of interest.
• Chemical Reference Standard: Provides a high-purity, isotopically labeled reference material for quality control and regulatory submissions in pharmaceutical manufacturing.

Basic Information

Item	Detail
Product Name	Vanillylamine-D3 Hydrochloride
CAS No.	1217899-51-8
Molecular Formula	C8H8D3ClNO2
Molecular Weight	202.66 g/mol (for monoisotopic mass)
Synonyms	4-Hydroxy-3-methoxybenzylamine-D3 hydrochloride; 3-Methoxy-4-hydroxybenzylamine-D3 hydrochloride; Vanillamine-D3 HCl; 4-(Aminomethyl)-2-methoxyphenol-D3 hydrochloride; Deuterated Vanillylamine HCl; (4-Hydroxy-3-methoxy-phenyl)methylamine-D3 hydrochloride; Capsaicin Intermediate-D3
EINECS	Contact for details

Quality Control

Every batch of Vanillylamine-D3 Hydrochloride is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and isotopic enrichment meet the highest standards. Our quality assurance protocol includes HPLC, NMR, and mass spectrometry to verify chemical and isotopic purity. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (D3)	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.