Description

[2H3]- Voriconazole n-Oxide is a stable isotope-labeled analog of a key metabolite of the antifungal agent Voriconazole. This compound is essential for conducting precise and reliable quantitative bioanalytical studies, particularly in pharmacokinetic and metabolism research. It serves as a critical internal standard for scientists and researchers in pharmaceutical development and clinical diagnostics, ensuring accurate measurement of Voriconazole and its metabolites in complex biological matrices.

Application

• Used as an internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) for the quantification of Voriconazole and its metabolites in biological samples.
• Critical for pharmacokinetic (PK) and pharmacodynamic (PD) studies to understand the absorption, distribution, metabolism, and excretion of Voriconazole.
• Facilitates drug metabolism and disposition research in preclinical and clinical development stages.
• Enables high-accuracy therapeutic drug monitoring (TDM) in patient plasma or serum to optimize antifungal therapy.
• Supports bioequivalence and bioavailability studies for generic drug development.
• Essential in forensic and toxicological analysis for the precise detection of Voriconazole.

Basic Information

Product Name	[2H3]- Voriconazole n-Oxide
CAS No.	1217851-84-7
Molecular Formula	C16H11D3F3N5O3
Molecular Weight	381.33 g/mol
Synonyms	Deuterated Voriconazole N-Oxide; Voriconazole-d3 N-Oxide; (2R,3S)-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol-d3 1-Oxide; VRC-d3 N-Oxide; UK-109496-d3 N-Oxide; Deuterium Labeled Voriconazole Metabolite; Stable Isotope Labeled Voriconazole N-Oxide
EINECS	Contact for details

Quality Control

Our [2H3]- Voriconazole n-Oxide is manufactured under strict quality control protocols to ensure the highest isotopic purity and chemical integrity required for sensitive analytical applications. Each batch is accompanied by comprehensive analytical data, including NMR and Mass Spectrometry for structural confirmation and isotopic enrichment verification. Certificates of Analysis (COA) detailing purity, isotopic purity, and chromatographic data are provided to guarantee batch-to-batch consistency and traceability for regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 99.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.