Description

(R)-Casodex-D4 is a deuterium-labeled isotopologue of the active pharmaceutical ingredient (R)-Casodex, a non-steroidal anti-androgen. This stable isotope-labeled compound is a critical reference standard and internal standard for precise analytical quantification in pharmaceutical research and development. It is primarily utilized by analytical chemists and researchers in pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in bioanalytical method development, pharmacokinetic studies, and drug metabolism research.

Application

• Bioanalytical Method Development: Serves as a stable isotope-labeled internal standard for the accurate quantification of (R)-Casodex and its metabolites in biological matrices (e.g., plasma, serum) using LC-MS/MS.
• Pharmacokinetic (PK) and Pharmacodynamic (PD) Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Drug Metabolism and Metabolite Identification: Used in mass spectrometry-based studies to differentiate drug-derived metabolites from endogenous compounds, facilitating metabolite profiling and structural elucidation.
• Quality Control and Impurity Profiling: Acts as a reference standard for the identification and quantification of the (R)-enantiomer in active pharmaceutical ingredient (API) batches and finished drug products.
• Doping Control Analysis: Potential application as a reference material in sports anti-doping laboratories for the detection of prohibited anabolic agents.
• Forensic Toxicology: Used as a calibrant or standard in the confirmatory analysis of pharmaceuticals in forensic casework.

Basic Information

Product Name	(R)-Casodex-D4
CAS No.	1217826-87-3
Molecular Formula	C18H10D4F4N2O4S
Molecular Weight	430.41 g/mol
Synonyms	(R)-Bicalutamide-D4; (R)-N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl-d4)sulfonyl]-2-hydroxy-2-methylpropanamide; (R)-Bicalutamide (phenyl-d4); (R)-Bicalutamide (phenyl ring-d4); (R)-Bicalutamide-d4; (R)-Casodex (phenyl-d4); Bicalutamide-D4 (R-enantiomer); Bicalutamide (R)-Isomer-d4
EINECS	Contact for details

Quality Control

Our (R)-Casodex-D4 is manufactured under strict quality control protocols to ensure the highest standards of isotopic purity and chemical identity. Each batch is characterized using advanced analytical techniques including NMR (¹H, ¹³C, ¹⁹F) and high-resolution mass spectrometry (HRMS) to confirm deuteration level and structural integrity. Purity is determined by validated HPLC and/or UPLC methods. A comprehensive Certificate of Analysis (CoA) is provided with each shipment, detailing batch-specific results for identity, chemical purity, isotopic purity, and residual solvents in compliance with relevant ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, 15-25°C (59-77°F). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (Deuteration)	≥98 atom % D
Isomeric Purity (Enantiomeric Excess)	≥99.0% ee
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.