Description

(S)-Cinacalcet Hydrochloride is the pharmacologically active enantiomer of the calcimimetic agent cinacalcet. This high-purity chiral intermediate is critical for the development and manufacturing of targeted therapies for disorders of calcium metabolism. It is primarily required by pharmaceutical R&D laboratories and API manufacturers focused on producing enantiomerically pure active pharmaceutical ingredients (APIs).

Application

• Active Pharmaceutical Ingredient (API) Intermediate: Key chiral building block in the synthesis of the calcimimetic drug (S)-Cinacalcet.
• Pharmaceutical Research & Development: Used in preclinical and clinical studies to investigate the efficacy and safety of the enantiopure compound.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Process Chemistry & Scale-Up: Employed in optimizing and scaling synthetic routes for commercial API production under GMP guidelines.
• Metabolic Disorder Therapeutics: Targeted for the development of treatments for secondary hyperparathyroidism in patients with chronic kidney disease and for hypercalcemia in parathyroid carcinoma.

Basic Information

Product Name	(S)-Cinacalcet Hydrochloride
CAS No.	1217809-88-5
Molecular Formula	C22H23ClF3N • HCl
Molecular Weight	434.34 g/mol (as hydrochloride salt)
Synonyms	(S)-N-[1-(R)-1-Naphthyl)ethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine Hydrochloride; (S)-Cinacalcet HCl; (S)-AMG 073 Hydrochloride; Sensipar (S)-Enantiomer Hydrochloride; (S)-Mimpara Hydrochloride; (1S)-1-(Naphthalen-1-yl)-N-[3-(trifluoromethyl)phenyl]ethanamine Hydrochloride; (S)-α-Methyl-N-[3-(trifluoromethyl)phenyl]-1-naphthaleneethanamine Hydrochloride
EINECS	Contact for details

Quality Control

Our (S)-Cinacalcet Hydrochloride is manufactured and tested to meet stringent quality standards suitable for pharmaceutical development. We employ advanced chiral analytical techniques, including HPLC and spectroscopic methods, to ensure high enantiomeric purity and chemical identity. A comprehensive Certificate of Analysis (COA) detailing purity, chiral excess, and impurity profiles is provided with each batch to support regulatory filings and quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.