Description

(R)-Fluoxetine-D5 Hydrochloride is a high-purity, isotopically labeled internal standard critical for modern analytical chemistry. This deuterated compound is specifically designed for use in quantitative mass spectrometry, providing unmatched accuracy and reliability in bioanalytical studies. It is an essential tool for pharmaceutical researchers, clinical laboratories, and forensic toxicologists requiring precise measurement of fluoxetine and its metabolites in complex biological matrices.

Application

• Quantitative Bioanalysis: Serves as a stable isotope-labeled internal standard (SIL-IS) for the accurate quantification of fluoxetine and norfluoxetine in plasma, serum, and tissue samples via LC-MS/MS.
• Pharmacokinetic & Metabolism Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Therapeutic Drug Monitoring (TDM): Critical for ensuring accurate assay results in clinical settings to optimize patient dosing of fluoxetine.
• Forensic & Clinical Toxicology: Used in confirmatory testing for fluoxetine in workplace drug testing, post-mortem analysis, and cases of suspected overdose.
• Method Development & Validation: A key component in developing and validating robust, regulatory-compliant analytical methods (e.g., following FDA/EMA bioanalytical guidelines).
• Reference Material for Quality Control: Acts as a certified reference material (CRM) to ensure the accuracy and precision of in-house analytical methods in quality control laboratories.

Basic Information

Product Name	(R)-Fluoxetine-D5 Hydrochloride
CAS No.	1217764-54-9
Molecular Formula	C17H13D5ClF3NO
Molecular Weight	345.79 g/mol
Synonyms	(R)-N-Methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propylamine-D5 Hydrochloride; (R)-Fluoxetine-d5 HCl; Dexfluoxetine-d5 Hydrochloride; (R)-Lilly 110140-d5 Hydrochloride; (R)-Prozac-d5 Hydrochloride; (+)-Fluoxetine-d5 Hydrochloride; (3R)-N-Methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]-1-propanamine-d5 Hydrochloride
EINECS	Contact for details

Quality Control

Every batch of (R)-Fluoxetine-D5 Hydrochloride is manufactured and tested under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive testing including assay, chiral purity, isotopic enrichment (D5), and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, containing batch-specific data from advanced analytical techniques (HPLC, GC, NMR, MS). Our quality commitment supports compliance with cGMP and ICH guidelines for reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant and inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Assay (HPLC)	≥98.0% (anhydrous basis)
Chiral Purity (HPLC)	≥99.0% (R)-enantiomer
Isotopic Enrichment (MS)	≥98.0 atom % D (D5)
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.