Description

(1S,4S)-4-(3,4-Dichlorophenyl)-n-(Trideuteriomethyl)-1,2,3,4-Tetrahydronaphthalen-1-Amine:Hydrochloride is a high-purity deuterated compound primarily used as a critical reference standard and metabolite in advanced pharmaceutical research and development. This compound is essential for applications requiring precise analytical quantification, such as pharmacokinetic studies and drug metabolism and safety testing. It is specifically designed for use by pharmaceutical companies, contract research organizations (CROs), and academic laboratories focused on developing and validating bioanalytical methods.

Application

• Pharmaceutical Reference Standard: Used as a certified standard for the quantification of active pharmaceutical ingredients (APIs) and their metabolites in complex biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK): Serves as a stable isotope-labeled internal standard in LC-MS/MS and GC-MS analyses to ensure accurate and reliable data in absorption, distribution, metabolism, and excretion (ADME) studies.
• Bioanalytical Method Development: Critical for developing, validating, and transferring robust analytical methods in compliance with regulatory guidelines (e.g., FDA, EMA).
• Clinical and Pre-clinical Research: Enables precise tracking and measurement of drug compounds and their deuterated analogs in plasma, serum, urine, and tissue samples.
• Impurity Profiling and Characterization: Aids in the identification and quantification of process-related impurities and degradation products during drug substance development.
• Isotope Dilution Mass Spectrometry (IDMS): Employed in high-precision quantitative analysis where maximum accuracy and minimal matrix effects are required.

Basic Information

Product Name	(1S,4S)-4-(3,4-Dichlorophenyl)-n-(Trideuteriomethyl)-1,2,3,4-Tetrahydronaphthalen-1-Amine:Hydrochloride
CAS No.	1217741-83-7
Molecular Formula	C18H17D3Cl2N•HCl
Molecular Weight	Contact for details
Synonyms	(1S,4S)-4-(3,4-Dichlorophenyl)-N-(trideuteriomethyl)-1,2,3,4-tetrahydronaphthalen-1-amine hydrochloride; Deuterated (1S,4S)-4-(3,4-Dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine hydrochloride; (1S,4S)-4-(3,4-Dichlorophenyl)-N-(CD3)-1,2,3,4-tetrahydro-1-naphthylamine hydrochloride; d3-(1S,4S)-4-(3,4-Dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine HCl; 1,2,3,4-Tetrahydro-N-(trideuteriomethyl)-4-(3,4-dichlorophenyl)-1-naphthalenamine hydrochloride (1S,4S)-
EINECS	Contact for details

Quality Control

Our deuterated compounds are manufactured under strict quality control protocols to ensure the highest standards of chemical purity and isotopic enrichment. Each batch is fully characterized using advanced analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) is provided, detailing purity, isotopic purity (D-enrichment), and analytical data. Our quality system supports compliance with cGMP and ISO standards for reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.