Description

Normethyl Fentanyl-D3 Hydrochloride Salt is a stable isotope-labeled internal standard critical for accurate quantitative analysis in forensic and clinical research. This high-purity compound is essential for ensuring the precision and reliability of mass spectrometry-based methods, such as LC-MS/MS, by correcting for variations in sample preparation and instrument response. It is primarily utilized by analytical laboratories, forensic toxicologists, and pharmaceutical researchers conducting method development, drug metabolism studies, and substance abuse testing.

Application

• Quantitative Internal Standard for Mass Spectrometry (LC-MS/MS, GC-MS): Serves as a critical reference compound for the accurate quantification of fentanyl analogs and metabolites in complex biological matrices.
• Forensic Toxicology and Drug Testing: Enables precise identification and measurement of illicit substances in urine, blood, and hair samples for legal and workplace testing programs.
• Clinical Research and Pharmacokinetic Studies: Used to track drug absorption, distribution, metabolism, and excretion (ADME) with high accuracy in human and animal studies.
• Pharmaceutical Method Development and Validation: Essential for developing, optimizing, and validating robust analytical methods in compliance with regulatory guidelines (e.g., FDA, EMA).
• Reference Material for Certified Standards: Acts as a high-purity component in the preparation of certified reference materials (CRMs) and quality control samples.
• Metabolite Identification and Profiling: Aids in the structural elucidation and quantification of drug metabolites in biological systems.

Basic Information

Product Name	Normethyl Fentanyl-D3 Hydrochloride Salt
CAS No.	1217732-80-3
Molecular Formula	C₂₂H₂₅D₃N₂O • HCl
Molecular Weight	Contact for details
Synonyms	N-Phenethyl-4-(N-phenylpropionamido)piperidine-D3 Hydrochloride; N-Desmethyl Fentanyl-D3 HCl; Fentanyl Impurity D-D3 Hydrochloride; N-(1-Phenethylpiperidin-4-yl)-N-phenylpropionamide-D3 Hydrochloride; Norfentanyl-D3 HCl; Fentanyl-d3 Related Compound A; Deuterated Normethyl Fentanyl HCl
EINECS	Contact for details

Quality Control

Every batch of Normethyl Fentanyl-D3 Hydrochloride Salt is manufactured and tested under strict quality management systems. We guarantee high chemical purity and isotopic enrichment, supported by comprehensive analytical data including NMR, HPLC, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity (by HPLC), isotopic purity, and other critical parameters to ensure compliance with research and forensic standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant and inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (Mass Spec)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Maximum Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.