Description

Ent Atomoxetine-D3, Hydrochloride is a deuterium-labeled isotopologue of the selective norepinephrine reuptake inhibitor atomoxetine, used as a critical internal standard in quantitative bioanalytical research. This high-purity reference material is essential for ensuring the accuracy and reliability of mass spectrometry-based assays, particularly in pharmacokinetic and metabolism studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities focused on neuropharmacology and drug development.

Application

• Internal Standard for LC-MS/MS Analysis: Serves as a stable isotope-labeled internal standard for the precise quantification of atomoxetine and its metabolites in biological matrices such as plasma, serum, and urine.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in clinical and preclinical research.
• Method Development and Validation: A key component in developing, optimizing, and validating robust bioanalytical methods compliant with FDA, EMA, and ICH guidelines.
• Doping Control and Forensic Analysis: Used in specialized testing for the detection and confirmation of atomoxetine in forensic and anti-doping applications.
• Metabolite Identification and Profiling: Aids in the identification and structural elucidation of drug metabolites using high-resolution mass spectrometry.
• Quality Control in Reference Material Production: Employed as a calibrant or system suitability check in the production and certification of other reference standards.

Basic Information

Product Name	Ent Atomoxetine-D3, Hydrochloride
CAS No.	1217703-95-1
Molecular Formula	C17H18D3NO•HCl
Molecular Weight	308.85 g/mol (approx.)
Synonyms	Atomoxetine-d3 hydrochloride; (R)-N-Methyl-3-phenyl-3-(o-tolyloxy)propylamine-d3 hydrochloride; (R)-Tomoxetine-d3 hydrochloride; LY-139603-d3; (R)-(-)-Tomoxetine-d3 hydrochloride; (3R)-N-Methyl-3-(2-methylphenoxy)-3-phenylpropan-1-amine-d3 hydrochloride
EINECS	Contact for details

Quality Control

Every batch of Ent Atomoxetine-D3, Hydrochloride is manufactured and tested under strict quality management systems. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic techniques, to ensure compliance with the high-purity standards required for analytical reference materials. Certificates of Analysis (COA) detailing batch-specific purity, isotopic enrichment, and analytical data (e.g., HPLC, NMR, MS) are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. Keep the container tightly sealed in a cool, dry, and well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (D3)	≥98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.