Description

7-Ethyl-10-(4-[[Benzylcarbamoyl]Amino]-1-Piperidino)Carbonyloxycamptothecin is a high-purity, semi-synthetic derivative of the potent topoisomerase I inhibitor, camptothecin. This compound is a critical pharmaceutical intermediate designed for the research and development of next-generation anticancer therapeutics. It is primarily utilized by pharmaceutical R&D laboratories and biotech companies focused on oncology drug discovery and advanced formulation studies.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel, targeted chemotherapeutic agents.
• Oncology Research: Used in biochemical and pharmacological studies to investigate mechanisms of topoisomerase I inhibition and tumor cell apoptosis.
• Drug Discovery & Development: A vital starting material for medicinal chemistry programs aimed at improving the solubility, stability, and efficacy of camptothecin analogs.
• Reference Standard: Employed as a high-purity analytical standard for quality control and method validation in API (Active Pharmaceutical Ingredient) manufacturing.
• Preclinical Studies: Utilized in in vitro and in vivo models to evaluate the pharmacokinetics, biodistribution, and antitumor activity of new drug candidates.

Basic Information

Product Name	7-Ethyl-10-(4-[[Benzylcarbamoyl]Amino]-1-Piperidino)Carbonyloxycamptothecin
CAS No.	1217686-49-1
Molecular Formula	C36H37N5O6
Molecular Weight	635.71 g/mol
Synonyms	7-Ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin; Benzylcarbamoyl Camptothecin Derivative; Camptothecin, 7-ethyl-10-[4-[(phenylmethyl)amino]carbonyl]-1-piperidinyl]carbonyl]oxy]-; (S)-7-Ethyl-10-(4-(benzylcarbamoyl)piperidin-1-yl)carbonyloxycamptothecin; 7-Ethyl-10-(4-(benzylcarbamoyl)piperidin-1-yl)carbonyloxycamptothecin; Camptothecin analog 1217686-49-1; CPT derivative with benzylcarbamoyl piperidine moiety
EINECS	Contact for details

Quality Control

Our 7-Ethyl-10-(4-[[Benzylcarbamoyl]Amino]-1-Piperidino)Carbonyloxycamptothecin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by spectroscopic methods, to ensure it meets the stringent requirements for pharmaceutical research. Certificates of Analysis (COA) detailing batch-specific results are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere. Allow the container to reach room temperature in a desiccator before opening to prevent condensation. Store away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.