Description

Demecolcine-D3 is a deuterated analog of the potent alkaloid demecolcine, a compound of significant interest in biochemical and pharmacological research. This stable isotope-labeled compound is essential for use as an internal standard in advanced analytical techniques, ensuring precise quantification and reliable data integrity. It is primarily utilized by research institutions, pharmaceutical development laboratories, and contract research organizations (CROs) engaged in metabolic studies, pharmacokinetic research, and high-precision LC-MS/MS method development.

Application

• As a stable isotope-labeled internal standard for the accurate quantification of demecolcine in biological matrices via LC-MS/MS.
• In pharmacokinetic and metabolic studies to investigate the absorption, distribution, metabolism, and excretion (ADME) profiles of demecolcine.
• For method development and validation in analytical laboratories to ensure regulatory compliance and data accuracy.
• In biomedical research focusing on the mechanisms of cell cycle inhibition and spindle poison activity.
• Use in clinical research and bioanalytical assays for therapeutic drug monitoring and toxicology studies.

Basic Information

Product Name	Demecolcine-D3
CAS No.	1217668-72-8
Molecular Formula	C21H22D3NO5
Molecular Weight	368.45 g/mol (approx.)
Synonyms	Demecolcine-d3; Colcemid-d3; N-Deacetyl-N-methylcolchicine-d3; (S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide-d3; O-Methylandrocymbine-d3; Deacetylcolchicine methyl ether-d3; Colecemid-d3
EINECS	Contact for details

Quality Control

Our Demecolcine-D3 is produced under strict quality management protocols to ensure the highest standards of isotopic purity and chemical integrity, critical for its role as an analytical standard. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for isotopic enrichment, chemical purity, and identity confirmation. We adhere to relevant industry guidelines to support research requiring reliable and traceable reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label/COA. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.