Description

Trans 1-Benzyl-4-(4-Fluorophenyl)-3-Methylsulfonatepiperidine-D4 is a high-purity, deuterated piperidine derivative used as a critical intermediate in advanced pharmaceutical research and development. Its primary value lies in its role as a stable isotope-labeled building block, enabling precise metabolic and pharmacokinetic studies for new drug candidates. This compound is essential for researchers and manufacturers in the pharmaceutical industry, particularly those developing and analyzing central nervous system (CNS) agents and other specialized therapeutics.

Application

• Pharmaceutical Intermediate: A key deuterated synthon in the synthesis of novel drug molecules, particularly for neurological and psychiatric applications.
• Metabolic Tracer: Used in drug metabolism and pharmacokinetics (DMPK) studies to track the fate of drug compounds in biological systems using mass spectrometry.
• Reference Standard: Serves as an internal standard for the quantitative analysis of non-deuterated analogs in bioanalytical methods, ensuring accuracy and reliability.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to investigate the impact of deuterium incorporation on drug efficacy and safety profiles.
• Isotope Labeling: Facilitates the production of deuterium-labeled active pharmaceutical ingredients (APIs) for clinical trials and advanced research.

Basic Information

Product Name	Trans 1-Benzyl-4-(4-Fluorophenyl)-3-Methylsulfonatepiperidine-D4
CAS No.	1217654-31-3
Molecular Formula	C19H18D4FNO3S
Molecular Weight	363.47 g/mol
Synonyms	1-Benzyl-4-(4-fluorophenyl)-3-(methylsulfonyloxy)piperidine-d4; 3-Methylsulfonatepiperidine-D4, 1-Benzyl-4-(4-Fluorophenyl)-, trans-; 1-Benzyl-4-(p-fluorophenyl)-3-(methylsulfonyloxy)piperidine-d4; trans-1-Benzyl-4-(4-fluorophenyl)piperidin-3-yl methanesulfonate-d4; Deuterated Piperidine Sulfonate Ester; (3R,4S)-1-Benzyl-4-(4-fluorophenyl)piperidin-3-yl methanesulfonate-d4 (if stereochemistry is defined); BFP-Mesylate-D4
EINECS	Contact for details

Quality Control

Our Trans 1-Benzyl-4-(4-Fluorophenyl)-3-Methylsulfonatepiperidine-D4 is manufactured under strict quality systems to ensure batch-to-batch consistency and high isotopic purity. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as chemical purity, isotopic enrichment (D4), and impurity profiles. We adhere to cGMP guidelines for pharmaceutical intermediates, and our quality commitment ensures the material meets the stringent requirements for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D4, MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.