Description

(R)-Norfluoxetine CAS NO 1217648-64-0 is a high-purity chiral intermediate and metabolite of the widely used antidepressant fluoxetine. This compound is of significant value in pharmaceutical research and development, particularly for studying metabolic pathways and developing enantiomerically pure active pharmaceutical ingredients (APIs). It is primarily needed by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in neuropharmacology research, chiral synthesis, and the development of novel selective serotonin reuptake inhibitors (SSRIs).

Application

• Key chiral intermediate for the synthesis of enantiomerically pure fluoxetine and related compounds.
• Reference standard for analytical method development and validation in pharmaceutical quality control laboratories.
• Metabolite standard for pharmacokinetic and drug metabolism studies in preclinical and clinical research.
• Building block in medicinal chemistry for the design and synthesis of new central nervous system (CNS) active agents.
• Critical reagent for biochemical assays investigating serotonin transporter (SERT) inhibition and selectivity.
• Used in academic research to study the stereospecific effects of SSRIs and their metabolic pathways.

Basic Information

Product Name	(R)-Norfluoxetine
CAS No.	1217648-64-0
Molecular Formula	C16H16F3NO
Molecular Weight	295.30 g/mol
Synonyms	(R)-Norfluoxetine; (R)-N-Methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine; (R)-3-(Methylamino)-1-phenyl-1-(4-(trifluoromethyl)phenoxy)propane; (R)-Fluoxetine Metabolite; (R)-Desmethylfluoxetine; LY368514 (R-enantiomer); (R)-N-Methyl-γ-[4-(trifluoromethyl)phenoxy]benzenepropanamine
EINECS	Contact for details

Quality Control

Our (R)-Norfluoxetine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (R-enantiomer)
Related Substances (HPLC)	Total impurities ≤2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.