Description

(R)-(+)-Blebbistatin o-Benzoate is a highly specific, cell-permeable inhibitor of non-muscle myosin II ATPase activity. This compound is a chemically modified, more soluble derivative of the classic research tool Blebbistatin, designed to enhance its utility in cellular and biochemical studies. It is an essential reagent for researchers in cell biology, pharmacology, and drug discovery who require precise control over myosin II-dependent cellular processes such as cytokinesis, cell migration, and morphological changes.

Application

• Biochemical Research: Used as a potent and selective inhibitor to study the enzymatic activity and regulation of non-muscle myosin II in vitro.
• Cell Biology Studies: Critical for investigating myosin II's role in fundamental cellular functions including cytokinesis, cell adhesion, and actin cytoskeleton dynamics.
• Pharmacology & Drug Discovery: Serves as a key reference compound and tool molecule in high-throughput screening assays and target validation for conditions involving aberrant cell motility and division.
• Neuroscience Research: Applied in studies of neuronal growth cone guidance and synaptic plasticity where myosin II activity is implicated.
• Cancer Research: Utilized to probe the mechanisms of tumor cell invasion, metastasis, and resistance, which are often myosin II-dependent.
• Developmental Biology: A vital tool for examining morphogenetic movements and tissue patterning during embryonic development.

Basic Information

Item	Detail
Product Name	(R)-(+)-Blebbistatin o-Benzoate
CAS No.	1217635-67-0
Molecular Formula	C27H23BrN2O4
Molecular Weight	519.39 g/mol
Synonyms	(+)-Blebbistatin o-Benzoate; (R)-Blebbistatin Benzoate; Blebbistatin Benzoate Derivative; Benzoic Acid (R)-Blebbistatin Ester; Myosin II Inhibitor (R)-(+)-o-Benzoate; 4-[(3aS,4R,6S,7aR)-6-Hydroxy-1,3a,5,7a-tetrahydro-4H-furo[3,4-c]pyridin-4-yl]-N-(1,3-benzothiazol-2-yl)-2-bromobenzamide o-Benzoate; (R)-Enantiomer of Blebbistatin Benzoate
EINECS	Contact for details

Quality Control

Our (R)-(+)-Blebbistatin o-Benzoate is manufactured under strict quality systems to ensure batch-to-batch consistency and high chemical purity, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to ISO guided standards, and our quality protocols are designed to meet the rigorous demands of the global life sciences research community.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. For short-term use, the product may be stored at 2-8°C. Allow the vial to warm to room temperature before opening to minimize moisture condensation. Keep the container tightly sealed in a dry and well-ventilated place.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.