Description

7-Ethyl-20(R)-Camptothecin is a potent semi-synthetic derivative of the natural alkaloid camptothecin, specifically engineered for enhanced pharmacological properties. This compound is a critical intermediate and active pharmaceutical ingredient (API) in the development of novel topoisomerase I inhibitor-based chemotherapeutics. It is primarily sought by pharmaceutical R&D departments, biotechnology firms, and contract manufacturing organizations (CMOs) engaged in oncology drug discovery and advanced cancer therapy formulation.

Application

• Oncology Drug Development: Core scaffold for synthesizing next-generation chemotherapeutic agents targeting topoisomerase I.
• Pharmaceutical Intermediates: Serves as a high-purity building block for the production of more complex, water-soluble camptothecin analogs.
• Biochemical Research: Used as a reference standard and tool compound in cancer biology studies to investigate apoptosis and DNA damage mechanisms.
• Preclinical Formulation: Essential for formulating injectable or oral dosage forms for in vivo efficacy and pharmacokinetic studies.
• API Manufacturing: Active Pharmaceutical Ingredient for the commercial production of approved anti-cancer drugs.

Basic Information

Product Name	7-Ethyl-20(R)-Camptothecin
CAS No.	1217633-65-2
Molecular Formula	C22H20N2O4
Molecular Weight	376.41 g/mol
Synonyms	7-Ethylcamptothecin; 20(R)-7-Ethylcamptothecin; (R)-7-Ethylcamptothecin; 7-Et-CPT; SN-38 precursor; 7-Ethyl-20(R)-hydroxy-1H,5H,15H,17H-oxepino[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
EINECS	Contact for details

Quality Control

Our 7-Ethyl-20(R)-Camptothecin is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and chiral purity, to ensure it meets the stringent requirements for pharmaceutical development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Yellow to light yellow powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (20R isomer)
Single Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.