Description

Valnemulin Trifluoroacetic Acid Salt-D6 is a deuterated, isotopically labeled derivative of the pleuromutilin antibiotic valnemulin, specifically designed for use as an internal standard in advanced analytical applications. This high-purity compound is critical for ensuring accuracy and reliability in quantitative mass spectrometry, particularly in pharmacokinetic and residue depletion studies. It is an essential tool for researchers and quality control laboratories in the pharmaceutical, veterinary medicine, and food safety sectors who require precise and traceable analytical methods.

Application

• Internal Standard for LC-MS/MS: Primary use as a quantitative reference standard in liquid chromatography-tandem mass spectrometry for the analysis of valnemulin and its metabolites.
• Pharmaceutical Research & Development: Enables accurate pharmacokinetic (PK) and pharmacodynamic (PD) studies during drug development and bioequivalence testing.
• Veterinary Drug Residue Analysis: Critical for monitoring valnemulin residues in animal-derived food products (meat, milk, eggs) to ensure compliance with maximum residue limits (MRLs).
• Metabolite Identification and Profiling: Aids in the identification and quantification of drug metabolites in complex biological matrices.
• Quality Control & Method Validation: Used to validate and calibrate analytical methods in GLP/GMP-compliant quality control laboratories.
• Stability-Indicating Assays: Supports the development of assays to monitor the stability and degradation of valnemulin in formulations.

Basic Information

Product Name	Valnemulin Trifluoroacetic Acid Salt-D6
CAS No.	1217627-44-5
Molecular Formula	C31H47D6F3N2O5S
Molecular Weight	~ 622.8 g/mol
Synonyms	Valnemulin-d6 TFA Salt; Valnemulin (D6) Trifluoroacetate; Deuterated Valnemulin TFA Salt; (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-Ethenyl-5-hydroxy-4,6,9,10-tetramethyl-1-oxodecahydro-3a,9-propano-3aH-cyclopentacycloocten-8-yl [(2R)-2-amino-3,3,3-trideutero-2-methyl-1-oxo-3-[(1S)-1-[(2S,3S,4R)-3,4-dihydroxy-4-methylsulfonyloxan-2-yl]pyrrolidin-1-ium-1-yl]propan-2-yl]carbamate trifluoroacetate
EINECS	Contact for details

Quality Control

Our Valnemulin Trifluoroacetic Acid Salt-D6 is manufactured under strict quality systems to ensure the high purity and isotopic enrichment required for trace analysis. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as chemical purity, isotopic purity (D-enrichment), and chromatographic profile. We ensure compliance with relevant standards for reference materials, supporting method validation and regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This compound is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.