Description

R-(A’)-7-Desmethyl-8-Nitro Blebbistatin is a high-purity, enantiomerically pure chemical compound designed for advanced life science research and development. This specific derivative of blebbistatin is valued for its role as a potent and selective inhibitor of non-muscle myosin II ATPase activity, enabling precise cellular and molecular studies. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in cytoskeletal dynamics research, high-content screening, and the development of novel therapeutic pathways.

Application

• Cytoskeletal Research: A critical tool for studying actin-myosin interactions, cell motility, cytokinesis, and morphological changes in various cell types.
• Drug Discovery & Screening: Used in high-throughput and high-content screening assays to identify compounds that modulate myosin II function for potential therapeutic applications.
• Cardiovascular & Muscle Biology: Facilitates research into cardiac muscle contraction, smooth muscle function, and related disease mechanisms by selectively inhibiting myosin II.
• Neuroscience Studies: Applied in investigations of neuronal growth cone dynamics, synaptic plasticity, and other processes dependent on non-muscle myosin II.
• Cancer Research: Employed to probe the role of myosin II in tumor cell invasion, metastasis, and the regulation of the tumor microenvironment.
• Developmental Biology: Used to examine the role of myosin II in embryogenesis, tissue patterning, and morphogenetic movements.

Basic Information

Product Name	R-(A’)-7-Desmethyl-8-Nitro Blebbistatin
CAS No.	1217619-62-9
Molecular Formula	C18H15N3O4
Molecular Weight	337.33 g/mol
Synonyms	(R)-(-)-Blebbistatin; (R)-Blebbistatin; (-)-Blebbistatin; R-Blebbistatin; (R)-7-Desmethyl-8-nitroblebbistatin; (3aR)-2,3,3a,4-Tetrahydro-8-nitro-3a-hydroxy-6-phenyl-1H-pyrrolo[2,3-b]quinoxalin-1-one; Myosin II Inhibitor R-(-)-Blebbistatin
EINECS	Contact for details

Quality Control

Our R-(A’)-7-Desmethyl-8-Nitro Blebbistatin is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Each lot is subjected to comprehensive analytical testing, including chiral purity verification by HPLC. A detailed Certificate of Analysis (COA) providing identity, purity, and impurity profiles is supplied with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (R-enantiomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.