Description

n-Desethyl Milnacipran-D5 is a deuterated analog of a key metabolite of the antidepressant Milnacipran, serving as a high-purity, stable isotope-labeled internal standard. This compound is essential for ensuring the accuracy and reliability of quantitative bioanalytical methods, particularly in pharmacokinetic and metabolism studies. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in method development and validation for clinical and forensic analysis.

Application

• Internal Standard for LC-MS/MS: Used as a critical reference standard in liquid chromatography-tandem mass spectrometry (LC-MS/MS) for the precise quantification of Milnacipran and its metabolites in biological matrices.
• Pharmacokinetic Research: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical studies.
• Metabolite Profiling: Facilitates the identification and quantification of drug metabolites, aiding in the understanding of metabolic pathways.
• Bioanalytical Method Development & Validation: Provides a stable, non-interfering isotopic standard to establish robust, sensitive, and specific analytical assays.
• Forensic Toxicology: Supports accurate drug level determination in forensic investigations and doping control.
• Quality Control in Pharmaceutical Manufacturing: Can be employed in impurity profiling and ensuring batch-to-batch consistency of the active pharmaceutical ingredient (API).

Basic Information

Product Name	n-Desethyl Milnacipran-D5
CAS No.	1217609-30-7
Molecular Formula	C14H15D5N2O
Molecular Weight	233.34 g/mol
Synonyms	1-(1-Phenylcyclopropyl)-N,N-dimethyl-2-(methylamino)propanamide-D5; Desethyl Milnacipran D5; Milnacipran Desethyl Metabolite D5; (1R,2S)-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide Desethyl D5; F 2695 Desethyl-D5; F-2695 Desethyl-D5; n-Desethyl-Milnacipran-d5
EINECS	Contact for details

Quality Control

Our n-Desethyl Milnacipran-D5 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and determination of isotopic enrichment. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with the specifications required for sensitive analytical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.