Description

Zofenoprilat-D5 n-Ethyl Succinimide is a deuterated internal standard of the active metabolite of the ACE inhibitor Zofenopril, specifically designed for analytical applications. This high-purity compound is essential for ensuring the accuracy and reliability of quantitative mass spectrometry and chromatographic analyses in pharmaceutical research and development. It is primarily used by analytical chemists and researchers in pharmaceutical companies, contract research organizations (CROs), and regulatory testing laboratories for method development, validation, and bioanalytical studies.

Application

• Internal Standard for LC-MS/MS: Serves as a critical deuterated internal standard for the precise quantification of Zofenoprilat in complex biological matrices such as plasma, serum, and urine.
• Pharmaceutical R&D: Used in pharmacokinetic (PK) and pharmacodynamic (PD) studies to understand the metabolism and distribution of Zofenopril.
• Bioanalytical Method Development: Enables the development and validation of robust, sensitive, and specific analytical methods compliant with FDA, EMA, and ICH guidelines.
• Clinical Trial Support: Facilitates accurate drug level monitoring in patient samples during clinical trials for cardiovascular therapies.
• Quality Control & Impurity Profiling: Aids in the identification and quantification of related substances and degradation products in active pharmaceutical ingredient (API) batches.
• Metabolite Studies: Supports research into the metabolic pathways and stability of angiotensin-converting enzyme (ACE) inhibitors.

Basic Information

Product Name	Zofenoprilat-D5 n-Ethyl Succinimide
CAS No.	1217546-60-5
Molecular Formula	C22H20D5N2O5S
Molecular Weight	428.53 g/mol
Synonyms	(4S)-1-[(2S)-3-(Benzoylthio)-2-methylpropanoyl]-4-(phenylthio)-L-proline-d5 n-Ethyl Succinimide; Zofenoprilat D5; Zofenoprilat-d5 Succinimide Ester; Deuterated Zofenoprilat Internal Standard; (S)-1-[(S)-3-(Benzoylthio)-2-methylpropanoyl]-4-(phenylthio)-L-proline-d5 Ethyl Succinimide Ester; SQ 26,991-d5; SQ-26991-d5
EINECS	Contact for details

Quality Control

Every batch of Zofenoprilat-D5 n-Ethyl Succinimide is manufactured and analyzed under strict quality systems to ensure the highest standards of purity and isotopic enrichment required for analytical applications. Our products undergo rigorous quality testing, including advanced spectroscopic and chromatographic methods, to ensure compliance with industry standards. Certificates of Analysis (COA) detailing batch-specific data for purity, isotopic purity (D-enrichment), and identity are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.