Description

2-Formyl-4-(Trifluoromethyl)Phenylboronic Acid is a high-value, multifunctional boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its unique structure, featuring both a formyl group and a trifluoromethyl substituent on the aromatic ring, makes it an exceptionally versatile intermediate for constructing complex molecular architectures. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for applications in Suzuki-Miyaura cross-coupling reactions and as a precursor for more elaborate functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules containing trifluoromethyl groups, which are prized for their metabolic stability and lipophilicity.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the boronic acid functionality enables efficient carbon-carbon bond formation.
• Material Science Research: Employed in the development of novel organic electronic materials, liquid crystals, and metal-organic frameworks (MOFs) due to its ability to act as a directional linker.
• Suzuki-Miyaura Cross-Coupling: Serves as a pivotal reagent in palladium-catalyzed cross-coupling reactions to create biaryl and heterobiaryl structures, a cornerstone methodology in medicinal chemistry.
• Chemical Biology & Probe Development: Utilized in the design and synthesis of molecular probes and sensors that leverage boronic acid-diol interactions for detecting biological analytes.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	2-Formyl-4-(Trifluoromethyl)Phenylboronic Acid
CAS No.	1217501-35-3
Molecular Formula	C8H6BF3O3
Molecular Weight	217.94 g/mol
Synonyms	[2-Formyl-4-(trifluoromethyl)phenyl]boronic acid; 4-(Trifluoromethyl)-2-formylbenzeneboronic acid; 2-Carboxy-4-(trifluoromethyl)phenylboronic Acid (tautomeric form); 2-Formyl-4-trifluoromethylbenzeneboronic acid; 2-Formyl-α,α,α-trifluoro-p-tolylboronic acid; Boronic acid, B-[2-formyl-4-(trifluoromethyl)phenyl]-; 2-Formyl-4-CF3-Phenylboronic Acid
EINECS	Contact for details

Quality Control

Our 2-Formyl-4-(Trifluoromethyl)Phenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment, NMR for structural confirmation, and Karl Fischer titration for moisture content, to ensure it meets the high standards required for research and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.