Description

Fti 276 Trifluoroacetate Salt CAS NO 1217471-51-6 is a potent and selective inhibitor of the farnesyltransferase enzyme, a key target in oncological and biomedical research. This compound matters for its critical role in studying signal transduction pathways and the prenylation of proteins like Ras, which are implicated in various cancers and proliferative diseases. It is primarily needed by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on developing novel therapeutics for oncology, dermatology, and cardiovascular research.

Application

• Oncology Research: Used as a key biochemical tool to investigate the role of farnesyltransferase in cancer cell proliferation, survival, and metastasis, particularly in Ras-driven tumors.
• Signal Transduction Studies: Employed to inhibit protein prenylation, helping to elucidate downstream signaling pathways involved in cell growth and differentiation.
• Drug Discovery & Development: Serves as a reference standard and lead compound in high-throughput screening assays for identifying new farnesyltransferase inhibitors.
• Academic & Biomedical Research: Utilized in in vitro and in vivo models to study the therapeutic potential of FTase inhibition in diseases beyond cancer, such as progeria and parasitic infections.
• Biochemical Assay Development: Acts as a positive control in enzymatic assays to validate the activity and specificity of farnesyltransferase test systems.

Basic Information

Product Name	Fti 276 Trifluoroacetate Salt
CAS No.	1217471-51-6
Molecular Formula	C27H30F3N3O5
Molecular Weight	533.54 g/mol
Synonyms	Fti-276 TFA salt; FTI 276 trifluoroacetate; (2S)-2-[[(2S)-2-[[(2S,3E)-5-[[(1,1-Dimethylethoxy)carbonyl]amino]-1-(1H-imidazol-4-yl)-2-methyl-3-penten-1-yl]oxy]-3-phenyl-1-oxopropyl]amino]-4-(methylsulfonyl)butanoic acid trifluoroacetate; Farnesyltransferase Inhibitor 276 TFA; FTI-276 (TFA); N-[(2S)-2-[[(2S,3E)-5-[[(1,1-Dimethylethoxy)carbonyl]amino]-1-(1H-imidazol-4-yl)-2-methyl-3-penten-1-yl]oxy]-3-phenyl-1-oxopropyl]-L-methionine S-methyl sulfone Trifluoroacetate
EINECS	Contact for details

Quality Control

Our Fti 276 Trifluoroacetate Salt is manufactured under strict quality systems to ensure batch-to-batch consistency and reliability for critical research applications. Each lot undergoes rigorous analytical testing, including HPLC for purity, identity confirmation (IR, MS), and residual solvent analysis. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.