Description

L-Lysine 2Hcl (6-13C) CAS NO 1217466-44-8 is a stable isotope-labeled derivative of the essential amino acid L-Lysine, where the carbon atom at the 6-position is enriched with the 13C isotope. This compound is a critical tool for advanced research and analytical applications requiring precise metabolic tracing and quantification. It is primarily utilized by scientists and quality control professionals in pharmaceutical development, nutritional science, and biomedical research.

Application

• Internal Standard in Quantitative Analysis: Used as a stable isotope-labeled internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) for the accurate quantification of L-Lysine in complex biological matrices.
• Metabolic Pathway Tracing: Enables the study of protein metabolism, amino acid flux, and nutrient utilization in cell cultures, animal models, and human clinical trials.
• Pharmaceutical Research & Development: Facilitates pharmacokinetic (PK) and pharmacodynamic (PD) studies of peptide-based drugs and nutritional formulations containing lysine.
• Nutritional Science Research: Employed in studies investigating amino acid requirements, bioavailability of dietary proteins, and the metabolic fate of nutritional supplements.
• Proteomics and Biomarker Discovery: Serves as a key component in isotope-coded affinity tag (ICAT) and other labeling strategies for comparative protein expression analysis.
• Quality Control & Reference Standard: Acts as a high-purity certified reference material (CRM) for calibrating analytical instruments and validating methods in quality control laboratories.

Basic Information

Product Name	L-Lysine 2Hcl (6-13C)
CAS No.	1217466-44-8
Molecular Formula	C613CH15Cl2N2O2 *
Molecular Weight	Approx. 221.13 g/mol *
Synonyms	(6-13C)-L-Lysine dihydrochloride; L-Lysine-6-13C dihydrochloride; (S)-2,6-Diamino-(6-13C)hexanoic acid dihydrochloride; 13C Labeled L-Lysine HCl; Lysine-13C6 (positional isomer); H-Lys(13C6)-OH·2HCl; Isotopically labeled L-Lysine 2HCl
EINECS	Contact for details

* Molecular weight is approximate and varies with exact isotopic enrichment. Contact us for the exact certificate of analysis.

Quality Control

Every batch of our L-Lysine 2Hcl (6-13C) is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data for isotopic enrichment (by NMR or MS), chemical purity (by HPLC), chiral purity, and identity confirmation. Our standards align with the rigorous requirements for high-purity reference materials used in pharmaceutical and clinical research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccated conditions or storage at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Isotopic Enrichment (Atom % 13C)	≥ 99% at position 6
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Chiral Purity (HPLC)	≥ 99.0% L-isomer
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.