Description

L-Threonine-D5 is a stable isotope-labeled analog of the essential amino acid L-Threonine, where five hydrogen atoms are replaced by deuterium. This high-purity compound is critical for use as an internal standard in quantitative mass spectrometry, ensuring analytical accuracy and reliability. It is primarily utilized by research institutions, pharmaceutical companies, and CROs engaged in advanced metabolomics, proteomics, and pharmacokinetic studies.

Application

• Quantitative Mass Spectrometry (MS/MS, LC-MS, GC-MS): Serves as a crucial internal standard for the precise quantification of endogenous L-Threonine in complex biological matrices like plasma, serum, and tissue homogenates.
• Metabolomics & Biomarker Discovery: Enables accurate tracking of threonine metabolism and flux analysis in metabolic pathway studies for disease research.
• Pharmaceutical R&D: Used in drug metabolism and pharmacokinetics (DMPK) studies to monitor the absorption, distribution, metabolism, and excretion (ADME) of drug candidates.
• Clinical Research: Facilitates the development and validation of diagnostic assays for inborn errors of metabolism related to amino acid disorders.
• Nutritional Science: Applied in stable isotope tracer studies to investigate protein synthesis, turnover, and amino acid requirements.
• Quality Control in Amino Acid Analysis: Acts as a reference standard to validate and calibrate analytical methods in quality control laboratories.

Basic Information

Product Name	L-Threonine-D5
CAS No.	1217456-38-6
Molecular Formula	C₄H₄D₅NO₃
Molecular Weight	124.15 g/mol
Synonyms	(2S,3R)-2-Amino-3-hydroxy[3,3,4,4,4-D5]butanoic acid; L-Threonine (D5); (2S,3R)-2-Amino-3-hydroxybutyric acid-D5; Threonine-D5; (2S,3R)-Amino(3-hydroxybutyric acid)-D5; Deuterated L-Threonine; L-Threonine (pentadeutero); Stable Isotope Labeled L-Threonine
EINECS	Contact for details

Quality Control

Our L-Threonine-D5 is manufactured under strict quality systems to ensure the highest isotopic and chemical purity required for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (atom % D), chemical purity by HPLC, and confirmation of structure. We support compliance with relevant GMP/GLP guidelines for research use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation or storage under an inert atmosphere to maintain stability and isotopic integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98.0 atom % D
Chemical Purity	≥ 95.0% (by NMR)
Optical Rotation	[α]²⁰D = -28.0° to -30.0° (c=1 in H₂O)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.