Description

4-Methoxy Estrone-13C,D3 is a high-purity, stable isotope-labeled analog of the endogenous estrogen metabolite, 4-Methoxy Estrone. This compound is specifically designed for use as an internal standard in quantitative bioanalytical methods, providing exceptional accuracy and reliability in mass spectrometry-based assays. It is an essential tool for researchers and quality control laboratories in the pharmaceutical, clinical research, and forensic toxicology sectors who require precise measurement of estrogen metabolites in complex biological matrices.

Application

• Internal Standard for LC-MS/MS: Primary application as a quantitative internal standard for the accurate measurement of 4-Methoxy Estrone and related metabolites in biological samples (e.g., serum, plasma, urine).
• Clinical Research & Diagnostics: Enables precise profiling of estrogen metabolism pathways for studies in endocrinology, oncology (e.g., breast cancer research), and metabolic disorders.
• Pharmaceutical Development: Used in pharmacokinetic (PK) and pharmacodynamic (PD) studies during the development of hormone-based therapies to monitor drug metabolism and efficacy.
• Forensic & Doping Control: Supports accurate testing for endogenous steroid profiles in anti-doping programs and forensic investigations.
• Method Development & Validation: Critical for developing, validating, and ensuring the compliance of robust bioanalytical methods according to FDA, EMA, and other regulatory guidelines.

Basic Information

Item	Details
Product Name	4-Methoxy Estrone-13C,D3
CAS No.	1217437-34-7
Molecular Formula	C1913CH21D3O3
Molecular Weight	Contact for details
Synonyms	4-Methoxyestra-1,3,5(10)-trien-3-ol-17-one-13C,D3; 3-Hydroxy-4-methoxyestra-1,3,5(10)-trien-17-one-13C,D3; 4-Methoxy-13C,D3-Estrone; [13C,D3]-4-Methoxy Estrone; 4-MeO-E1-13C,D3; Labeled 4-Methoxy Estrone; Stable Isotope-Labeled 4-Methoxyestrone; Internal Standard for 4-Methoxyestrone
EINECS	Contact for details

Quality Control

Every batch of 4-Methoxy Estrone-13C,D3 is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive testing including HPLC for chemical purity and MS for isotopic enrichment verification. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific results for identity, purity, and isotopic abundance to support your regulatory submissions and ensure data integrity.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98%
Isotopic Purity	≥ 99 atom % 13C; ≥ 98 atom % D
Chemical Purity	≥ 95%
Solubility	Soluble in methanol, acetonitrile, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.