Description

Sibutramine-D7 Hydrochloride is a high-purity, deuterium-labeled internal standard essential for precise quantitative analysis in modern laboratories. This stable isotope-labeled compound is critical for ensuring the accuracy and reliability of mass spectrometry-based methods, particularly in pharmacokinetic and metabolic studies. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and regulatory testing facilities engaged in advanced analytical chemistry and bioanalytical method development.

Application

• Primary use as an internal standard for the accurate quantification of sibutramine and its metabolites in biological matrices via LC-MS/MS and GC-MS.
• Critical component in pharmacokinetic (PK) and bioequivalence studies for method validation and sample analysis.
• Enables reliable doping control and forensic analysis in sports and regulatory compliance testing.
• Supports drug metabolism and disposition (DMPK) research by tracing metabolic pathways.
• Used in the development and validation of high-throughput screening assays in pharmaceutical development.
• Facilitates quality control and stability testing of pharmaceutical formulations containing sibutramine.

Basic Information

Product Name	Sibutramine-D7 Hydrochloride
CAS No.	1217175-13-7
Molecular Formula	C17H19D7ClN • HCl
Molecular Weight	334.36 g/mol (approx.)
Synonyms	1-(4-Chlorophenyl)-N,N-dimethyl-α-(2-methylpropyl)-cyclobutanemethanamine-D7 Hydrochloride; (±)-Sibutramine-D7 Hydrochloride; Sibutramine-d7 HCl; Meridia-D7 Hydrochloride; Reductil-D7 Hydrochloride; [2,2,3,3,4,4,4-Heptadeuterio-2-butyl]-(4-chlorophenyl)-N,N-dimethyl-1-aminocyclobutane Methanamine Hydrochloride
EINECS	Contact for details

Quality Control

Every batch of Sibutramine-D7 Hydrochloride is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure exceptional isotopic purity and chemical identity. Our quality assurance protocol includes comprehensive characterization by NMR, HPLC, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming batch-specific data for isotopic enrichment, chemical purity, and assay. We adhere to stringent quality management principles suitable for research and analytical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. Upon receipt and after each use, ensure the container is sealed properly to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to structure
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Isotopic Purity (Deuterium Enrichment)	≥ 98.0 atom % D
Chemical Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.