Description

Bumetanide-D5 is a deuterated internal standard of the loop diuretic bumetanide, specifically labeled with five deuterium atoms. This high-purity compound is essential for ensuring accuracy and reliability in quantitative mass spectrometry-based analyses. It is primarily used by pharmaceutical research and development laboratories, contract research organizations (CROs), and analytical testing facilities. The product is critical for method development, validation, and bioanalytical studies requiring precise measurement of bumetanide.

Application

• Internal Standard for LC-MS/MS: Serves as a critical deuterated internal standard for the precise quantification of bumetanide in biological matrices (e.g., plasma, serum, urine) using liquid chromatography-tandem mass spectrometry (LC-MS/MS).
• Pharmacokinetic and Bioequivalence Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in clinical and preclinical research.
• Drug Metabolism Research: Used in metabolite identification and profiling studies to understand the metabolic pathways of bumetanide.
• Forensic and Clinical Toxicology: Supports the accurate detection and quantification of bumetanide in forensic analysis and therapeutic drug monitoring.
• Pharmaceutical Quality Control: Applied in analytical methods for the assay and impurity profiling of bumetanide in active pharmaceutical ingredients (APIs) and finished drug products.
• Regulatory Submissions: Provides the validated reference material required for supporting data in regulatory filings to agencies like the FDA and EMA.

Basic Information

Item	Detail
Product Name	Bumetanide-D5
CAS No.	1216739-35-3
Molecular Formula	C17H15D5N2O5S
Molecular Weight	369.44 g/mol (approx.)
Synonyms	3-(Aminosulfonyl)-5-(butylamino)-4-phenoxybenzoic-3,4,5,6,7-d5 acid; Bumetanide-d5; Bumetanide (phenyl-d5); 4-Phenoxy-3-(sulfamoylamino)-5-(butylamino)benzoic-3,4,5,6,7-d5 acid; Bumex-d5; Butymide-d5; Burinex-d5; Deuterated Bumetanide Internal Standard
EINECS	Contact for details

Quality Control

Our Bumetanide-D5 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and mass spectrometry, to confirm identity, purity, and deuterium enrichment. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity. For long-term storage, consider desiccants or storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to reference mass spectrum
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Enrichment)	≥ 98 atom % D
Chemical Purity (by HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.