Description

Ethyl Difluoro[5-(Trifluoromethyl)-Pyridin-2-Yl]Acetate is a high-value fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its molecular structure, featuring both difluoroacetate and trifluoromethylpyridine moieties, makes it an essential precursor for introducing fluorine atoms into complex molecules, thereby modulating their physicochemical and biological properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, oncology, and anti-infective agents.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms enhance bioavailability and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing novel fluorinated ligands used in catalysis and material science applications.
• Fluorine Chemistry Research: An important reagent for academic and industrial research focused on organofluorine chemistry and the synthesis of complex fluorinated heterocycles.
• Material Science Precursor: Potential use in the development of specialty polymers and liquid crystals with unique electronic and surface properties.

Basic Information

Product Name	Ethyl Difluoro[5-(Trifluoromethyl)-Pyridin-2-Yl]Acetate
CAS No.	1216700-64-9
Molecular Formula	C10H6F5NO2
Molecular Weight	267.15 g/mol
Synonyms	Ethyl 2,2-Difluoro-2-[5-(trifluoromethyl)pyridin-2-yl]acetate; 2-Pyridineacetic acid, 2,2-difluoro-α,α,α,5-tetramethyl-, ethyl ester; Ethyl 2,2-Difluoro-2-(5-trifluoromethyl-2-pyridyl)acetate; Ethyl [Difluoro(5-trifluoromethyl-2-pyridyl)]acetate; 1216700-64-9; Ethyl α,α-Difluoro-α-[5-(trifluoromethyl)-2-pyridyl]acetate
EINECS	Contact for details

Quality Control

Our Ethyl Difluoro[5-(Trifluoromethyl)-Pyridin-2-Yl]Acetate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong bases and incompatible materials. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.