Description

n-Acetyl Desethyl Chloroquine-D4 is a stable isotope-labeled analog of a key chloroquine metabolite, specifically deuterated at four positions. This compound is essential for high-precision analytical work, serving as a critical internal standard for accurate quantification in complex biological matrices. It is primarily required by pharmaceutical research laboratories, contract research organizations (CROs), and analytical service providers engaged in pharmacokinetic studies, drug metabolism research, and bioanalytical method development.

Application

• Internal Standard for LC-MS/MS: Used as a deuterated internal standard in Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) for the precise quantification of chloroquine and its metabolites in biological samples like plasma, serum, and urine.
• Pharmacokinetic (PK) and Toxicokinetic (TK) Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical research.
• Bioanalytical Method Development and Validation: Critical for developing robust, sensitive, and specific analytical methods compliant with FDA, EMA, and ICH guidelines.
• Drug Metabolism and Disposition Research: Facilitates the study of metabolic pathways and the identification of metabolite structures in drug discovery and development.
• Forensic and Anti-Doping Analysis: Supports accurate detection and confirmation of chloroquine and related compounds in forensic toxicology and sports anti-doping controls.
• Reference Material for Quality Control: Serves as a certified reference material (CRM) for calibrating instruments and ensuring data integrity in analytical laboratories.

Basic Information

Product Name	n-Acetyl Desethyl Chloroquine-D4
CAS No.	1216619-20-3
Molecular Formula	C16H22D4ClN3O
Molecular Weight	299.86 g/mol (for deuterated form)
Synonyms	N-Acetyl-4-amino-7-chloroquinoline-D4; N-Acetyl-desethylchloroquine-D4; N-Acetyl-DDCQ-D4; Chloroquine Metabolite D4 Internal Standard; 4-Acetamido-7-chloroquinoline-D4; Desethylchloroquine N-Acetyl-D4; AQ-13 Metabolite-D4 (labeled); [²H₄]-n-Acetyl Desethyl Chloroquine
EINECS	Contact for details

Quality Control

Our n-Acetyl Desethyl Chloroquine-D4 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and isotopic enrichment suitable for sensitive bioanalytical applications. Certificates of Analysis (COA) detailing purity, isotopic purity (D-enrichment), and all analytical results are provided to guarantee traceability and compliance with research and regulatory standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccant use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.