Description

Sibutramine-D6 is a deuterium-labeled analog of the pharmaceutical compound sibutramine, specifically designed for use as an internal standard in quantitative analytical methods. This high-purity stable isotope-labeled compound is essential for ensuring the accuracy and reliability of mass spectrometry-based analyses, particularly in pharmacokinetic and metabolic studies. It is a critical tool for researchers and quality control laboratories in the pharmaceutical, forensic, and clinical diagnostics sectors who require precise and reproducible data.

Application

• Primary use as an internal standard for the quantification of sibutramine and its metabolites via LC-MS/MS and GC-MS.
• Facilitates drug metabolism and pharmacokinetic (DMPK) studies in pharmaceutical research and development.
• Enables accurate analysis in forensic toxicology for the detection of sibutramine in biological samples.
• Supports quality control and method validation in analytical laboratories for dietary supplements and pharmaceutical products.
• Used in clinical research to study the disposition and clearance of sibutramine.
• Essential for bioanalytical method development requiring high specificity and minimal isotopic interference.

Basic Information

Product Name	Sibutramine-D6
CAS No.	1216544-25-0
Molecular Formula	C17H20D6ClN
Molecular Weight	285.88 g/mol
Synonyms	1-(4-Chlorophenyl)-N,N-dimethyl-α-(2-methylpropyl)-cyclobutanemethanamine-D6; (±)-Sibutramine-D6; Sibutramine d6; Meridia-D6; Reductil-D6; Sibutramine Deuterated; Sibutramine Internal Standard
EINECS	Contact for details

Quality Control

Our Sibutramine-D6 is manufactured under strict quality control protocols to ensure the highest isotopic purity and chemical stability required for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results from advanced spectroscopic and chromatographic tests, including NMR, HPLC, and MS. We are committed to supplying reference materials that meet the rigorous standards of pharmaceutical R&D and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term stability, consider storage at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.