Description

4-n-Acetylaminobenzene-13C6-Sulfonyl Chloride is a stable isotope-labeled derivative of a key sulfonyl chloride intermediate, where the aromatic ring is uniformly labeled with carbon-13 (13C6). This compound is essential for the synthesis of isotopically labeled molecules, providing a critical tool for precise analytical quantification and metabolic pathway tracing. It is primarily required by research institutions and pharmaceutical companies engaged in advanced drug development, pharmacokinetic studies, and the production of internal standards for mass spectrometry.

Application

• Synthesis of Isotopically Labeled Standards: Used as a precursor for preparing carbon-13 labeled internal standards for Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) to ensure accurate quantitative analysis.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Enables the tracking of drug molecules and their metabolites in biological systems, providing critical data on absorption, distribution, metabolism, and excretion (ADME).
• Proteomics and Biomarker Research: Facilitates the development of isotope-coded affinity tags (ICAT) or other labeling reagents for comparative quantitative proteomics.
• Organic Synthesis Intermediate: Serves as a versatile building block for introducing the sulfonamide moiety into complex, labeled target molecules for various research applications.
• Environmental and Food Safety Testing: Used to create labeled analogs of pesticides, toxins, or contaminants for use as recovery standards in sophisticated analytical methods.

Basic Information

Product Name	4-n-Acetylaminobenzene-13C6-Sulfonyl Chloride
CAS No.	1216418-07-3
Molecular Formula	C136H8ClNO3S
Molecular Weight	~221.66 (for 13C6 labeled form)
Synonyms	4-Acetamidobenzenesulfonyl Chloride-13C6; N-Acetyl-4-aminobenzenesulfonyl Chloride-13C6; p-Acetamidobenzenesulfonyl Chloride-13C6; 4-(Acetylamino)benzenesulfonyl Chloride-13C6; ABSCl-13C6; Sulfacetamide Chloride-13C6; NSC 2211-13C6; 13C6-Labeled Sulfonyl Chloride Intermediate
EINECS	Contact for details

Quality Control

Our 4-n-Acetylaminobenzene-13C6-Sulfonyl Chloride is manufactured under strict quality systems to ensure the highest isotopic and chemical purity for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as isotopic enrichment (Atom % 13C), chemical purity by HPLC, and identity confirmation. We adhere to relevant standards for research chemicals, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (Atom % 13C)	≥ 99%
Chemical Purity (by NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.