Description

3-Chloro-3-(4'-Methoxy-3'-Sulfonamidophenyl)-2-Propylamine-Methyl-D3, Hydrochloride is a high-purity, deuterated chemical building block designed for advanced research and development. This compound is critical for applications requiring precise molecular labeling, such as in the development of internal standards for mass spectrometry and the study of metabolic pathways. It is primarily utilized by pharmaceutical R&D teams, analytical laboratories, and contract research organizations (CROs) engaged in drug discovery, bioanalytical method development, and pharmacokinetic studies.

Application

• Pharmaceutical Research: As a deuterated internal standard for the accurate quantification of parent compounds or metabolites in bioanalytical assays using LC-MS/MS.
• Drug Metabolism and Pharmacokinetics (DMPK): For tracing and studying the absorption, distribution, metabolism, and excretion (ADME) profiles of drug candidates.
• Proteomics and Metabolomics: Serving as a stable isotope-labeled reagent for relative and absolute quantification in complex biological samples.
• Chemical Synthesis: As a specialized intermediate in the synthesis of deuterated analogs of more complex active pharmaceutical ingredients (APIs) for patent extension or mechanistic studies.
• Quality Control & Method Validation: Employed in analytical laboratories to validate and ensure the accuracy, precision, and robustness of chromatographic methods.

Basic Information

Product Name	3-Chloro-3-(4'-Methoxy-3'-Sulfonamidophenyl)-2-Propylamine-Methyl-D3, Hydrochloride
CAS No.	1216389-46-6
Molecular Formula	C13H20ClD3N2O3S • HCl
Molecular Weight	~371.33 g/mol (for monoisotopic)
Synonyms	3-Chloro-3-(4-methoxy-3-sulfamoylphenyl)-2-propylamine-methyl-d3 hydrochloride; 2-Propylamine, 3-chloro-3-(4-methoxy-3-sulfamoylphenyl)-, methyl-d3, hydrochloride; Deuterated Sulfonamide Amine Hydrochloride; (3-Chloro-3-(4-methoxy-3-sulfonamidophenyl)propan-1-amine-methyl-d3) hydrochloride; Internal Standard for Sulfonamide Analogs; Stable Isotope-Labeled Building Block
EINECS	Contact for details

Quality Control

Every batch of 3-Chloro-3-(4'-Methoxy-3'-Sulfonamidophenyl)-2-Propylamine-Methyl-D3, Hydrochloride is manufactured under strict quality management systems. Our products undergo rigorous quality testing, including advanced spectroscopic and chromatographic techniques, to ensure compliance with research-grade standards and customer specifications. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic enrichment, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.