Description

5-Chloro-2-Ethoxy-4-Methylbenzenesulfonyl Chloride (Saltdata: Free) is a high-purity sulfonyl chloride derivative, a critical building block in advanced organic synthesis. This compound is valued for its role as a key electrophilic intermediate, enabling the introduction of the sulfonamide functional group into target molecules. It is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing new active ingredients, particularly for creating sulfonamide-based drugs and crop protection agents. CAS No. 1216234-07-9.

Application

This specialized sulfonyl chloride is a versatile reagent with primary applications in research and industrial synthesis.

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel sulfonamide-based active pharmaceutical ingredients (APIs), including potential diuretics, carbonic anhydrase inhibitors, and antibacterial agents.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and pesticides that utilize the sulfonamide moiety for enhanced efficacy and selectivity.
• Chemical Research & Development: Serves as a fundamental building block in medicinal chemistry for structure-activity relationship (SAR) studies and the creation of targeted compound libraries.
• Dye and Pigment Manufacturing: Employed in the synthesis of specialized sulfonated dyes and colorants, where the chlorosulfonyl group acts as an anchor for chromophore attachment.
• Polymer Modification: Can be used to introduce sulfonamide groups into polymer chains, altering properties like solubility, thermal stability, or biological activity for advanced material science applications.

Basic Information

Product Name	5-Chloro-2-Ethoxy-4-Methylbenzenesulfonyl Chloride (Saltdata: Free)
CAS No.	1216234-07-9
Molecular Formula	C9H10Cl2O3S
Molecular Weight	269.15 g/mol
Synonyms	4-Methyl-5-chloro-2-ethoxybenzenesulfonyl chloride; 2-Ethoxy-4-methyl-5-chlorobenzenesulfonyl chloride; 1-Chloro-4-ethoxy-2-methyl-5-sulfonylchloridebenzene; 5-Chloro-2-ethoxy-p-toluenesulfonyl chloride; Benzenesulfonyl chloride, 5-chloro-2-ethoxy-4-methyl-; CAS 1216234-07-9
EINECS	Contact for details

Quality Control

Our 5-Chloro-2-Ethoxy-4-Methylbenzenesulfonyl Chloride is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the exacting standards required for research and synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically by HPLC/NMR), and impurity profiles is provided with every shipment to guarantee traceability and support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.