Description

n-Despropyl Ropinirole-D3 is a deuterium-labeled internal standard of a key ropinirole metabolite, specifically designed for high-precision analytical applications. This compound is critical for ensuring accurate quantification and method validation in complex biological matrices, providing superior data integrity for research and development. It is an essential tool for pharmaceutical scientists, clinical researchers, and analytical laboratories focused on pharmacokinetic studies, drug metabolism research, and bioanalytical method development.

Application

• Primary use as a deuterated internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) bioanalysis.
• Quantification of ropinirole and its metabolites in pharmacokinetic (PK) and pharmacodynamic (PD) studies.
• Method development and validation for drug metabolism and disposition (DMPK) research.
• High-accuracy calibration in clinical research and therapeutic drug monitoring (TDM) protocols.
• Supporting regulatory submissions to agencies like the FDA and EMA by providing robust analytical data.
• Use in research investigating the metabolic pathways and clearance mechanisms of dopaminergic agents.

Basic Information

Product Name	n-Despropyl Ropinirole-D3
CAS No.	1215798-00-7
Molecular Formula	C13H14D3N3O
Molecular Weight	219.30 g/mol (for monoisotopic mass)
Synonyms	4-[2-(Dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-one-d3 (Despropyl); Ropinirole Despropyl Metabolite-d3; Ropinirole-d3 Despropyl Analog; SKF-101468 Despropyl-d3; Deuterated Ropinirole Internal Standard; D3-labeled Ropinirole Metabolite; 2H-Indol-2-one, 1,3-dihydro-4-[2-(dipropylamino)ethyl]-, d3- (9CI)
EINECS	Contact for details

Quality Control

This high-grade reference material is produced under strict quality control to ensure isotopic purity and chemical integrity suitable for sensitive analytical work. Each batch is characterized using advanced techniques including NMR and High-Resolution Mass Spectrometry (HRMS). A comprehensive Certificate of Analysis (COA) is provided, detailing assay, isotopic enrichment, and purity specifications. Our quality system supports compliance with GMP/GLP principles for research use.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This material is light-sensitive (store away from light). Keep the container sealed in a dry, cool environment to maintain long-term stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D3)	≥ 99.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.