Description

Ketorolac-D5 is a deuterated analog of the non-steroidal anti-inflammatory drug (NSAID) Ketorolac, specifically labeled with five deuterium atoms. This compound is a critical internal standard used in quantitative analytical methods, ensuring the highest accuracy and reliability in pharmaceutical research and quality control. It is essential for professionals in pharmaceutical development, contract research organizations (CROs), and analytical laboratories who require precise and stable isotopic labels for mass spectrometry (LC-MS/MS, GC-MS) and NMR applications.

Application

• Internal Standard for Bioanalysis: Primary use as a stable isotope-labeled internal standard in the quantification of Ketorolac in biological matrices (plasma, serum, urine) via LC-MS/MS.
• Pharmaceutical R&D: Enables accurate pharmacokinetic (PK), pharmacodynamic (PD), and metabolism studies during drug development.
• Quality Control & Assurance: Used in the validation of analytical methods and in the routine quality control testing of Ketorolac drug substances and finished products.
• Metabolite Identification: Aids in the identification and characterization of drug metabolites in complex samples.
• Forensic and Clinical Toxicology: Supports precise measurement of Ketorolac levels in forensic investigations and clinical settings.
• Method Development and Validation: Critical for developing robust, sensitive, and specific analytical protocols compliant with ICH, FDA, and EMA guidelines.

Basic Information

Product Name	Ketorolac-D5
CAS No.	1215767-66-0
Molecular Formula	C15H8D5NO3
Molecular Weight	260.30 g/mol (approx.)
Synonyms	(±)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid-d5; Ketorolac (phenyl-d5); Ketorolac-d5; Ketorolac (phenyl ring-d5); 2,3-Dihydro-1H-pyrrolizine-1-carboxylic acid, 5-benzoyl-, phenyl-d5; Deuterated Ketorolac; Ketorolac Internal Standard; Ketorolac-d5 (Cpd 12)
EINECS	Contact for details

Quality Control

Our Ketorolac-D5 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for chemical purity, NMR and MS for structural confirmation and isotopic enrichment, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (Deuterium Enrichment)	≥98.0 atom % D
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.