Description

Clozapine-D3 is a deuterium-labeled analog of the atypical antipsychotic clozapine, specifically designed for use as an internal standard in analytical chemistry. This stable isotope-labeled compound is essential for ensuring the accuracy and reliability of quantitative analyses, particularly in complex biological matrices. It is a critical tool for researchers and quality control laboratories in the pharmaceutical, forensic, and clinical diagnostics sectors who require precise measurement of clozapine levels.

Application

• Quantitative Bioanalysis: Serves as an internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) and Gas Chromatography-Mass Spectrometry (GC-MS) methods for the precise quantification of clozapine in plasma, serum, and other biological samples.
• Pharmacokinetic and Metabolism Studies: Used in ADME (Absorption, Distribution, Metabolism, and Excretion) research to track and quantify the parent drug and its metabolites, correcting for instrument variability and sample preparation losses.
• Therapeutic Drug Monitoring (TDM): Enables accurate and reliable measurement of clozapine concentrations in patient blood samples to optimize dosing regimens and ensure therapeutic efficacy while minimizing side effects.
• Forensic and Toxicology Analysis: Provides a definitive reference standard for the identification and quantification of clozapine in forensic investigations and toxicological screenings.
• Pharmaceutical Quality Control: Employed in the assay and impurity profiling of clozapine active pharmaceutical ingredients (APIs) and finished drug products to ensure batch-to-batch consistency and compliance with regulatory specifications.
• Method Development and Validation: A crucial component in developing, validating, and transferring robust analytical methods for clozapine across different laboratory settings.

Basic Information

Product Name	Clozapine-D3
CAS No.	1215691-72-7
Molecular Formula	C18H16D3ClN4
Molecular Weight	329.82 g/mol
Synonyms	8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine-D3; Clozapine (methyl-d3); Clozaril-D3; Leponex-D3; 5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(4-methyl-1-piperazinyl)-, methyl-d3; Deuterated Clozapine (3 deuterium atoms); Clozapine-d3 (methyl-d3) Internal Standard
EINECS	Contact for details

Quality Control

Our Clozapine-D3 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR and Mass Spectrometry for structural confirmation and isotopic purity, and HPLC for chemical purity assessment. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes batch-specific data on isotopic enrichment, chemical purity, and residual solvent levels, ensuring traceability and compliance with your research or quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C or as recommended on the product label or COA. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Isotopic Purity (Deuterium Content)	≥ 98 atom % D
Chemical Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.