Description

n-Acetyl Dapsone-D8 (Major) is a deuterated analog of the acetylated metabolite of dapsone, a compound of significant interest in pharmaceutical research and development. This high-purity, isotopically labeled standard is essential for ensuring accuracy and reliability in quantitative mass spectrometry-based analyses. It is primarily utilized by researchers and quality control laboratories in the pharmaceutical, contract research organization (CRO), and academic sectors for applications such as drug metabolism and pharmacokinetics (DMPK) studies, bioanalytical method development, and as an internal standard for precise quantification.

Application

• Internal Standard for LC-MS/MS: Serves as a critical, non-interfering internal standard for the accurate quantification of dapsone and its metabolites in complex biological matrices like plasma, serum, and urine.
• Drug Metabolism Studies (DMPK): Used in preclinical and clinical research to trace and quantify metabolic pathways, enabling a deeper understanding of drug disposition and clearance.
• Bioanalytical Method Development and Validation: Essential for developing, optimizing, and validating robust, sensitive, and specific analytical methods in compliance with regulatory guidelines (e.g., FDA, EMA).
• Pharmacokinetic/Pharmacodynamic (PK/PD) Modeling: Provides reliable data input for modeling drug exposure and effect relationships.
• Stable Isotope Dilution Assays: Employed in high-precision assays where the deuterated compound co-elutes with the analyte, correcting for losses during sample preparation and ionization variability.
• Reference Material for Quality Control: Acts as a certified reference material to ensure the accuracy and consistency of analytical results within and between laboratories.

Basic Information

Product Name	n-Acetyl Dapsone-D8 (Major)
CAS No.	1215635-13-4
Molecular Formula	C15H7D8N2O2S
Molecular Weight	284.39 g/mol
Synonyms	N-Acetyl Dapsone-d8; 4,4'-Sulfonylbis(2,3,5,6-tetradeuteroaniline) N-acetyl derivative; Dapsone N-acetate-d8; DADPS-d8; N-Acetyl-4,4'-diaminodiphenyl sulfone-d8; Deuterated N-Acetyl Dapsone; Acetyl Dapsone-d8; Internal Standard for Dapsone LC-MS
EINECS	Contact for details

Quality Control

Every batch of n-Acetyl Dapsone-D8 (Major) is manufactured and analyzed under strict quality management protocols. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic techniques, to ensure compliance with the high-purity standards required for analytical research. Certificates of Analysis (COA) detailing batch-specific purity, isotopic enrichment, and impurity profiles are available upon request to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the original container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0% (Area %)
Isotopic Enrichment	≥98 atom % D
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.