Description

Zopiclone-D8 is a deuterated analog of the widely used non-benzodiazepine sedative-hypnotic, Zopiclone. This stable isotope-labeled compound is an essential reference standard and internal standard for precise analytical quantification in research and development. It is primarily utilized by pharmaceutical companies, contract research organizations (CROs), and analytical laboratories engaged in pharmacokinetic studies, drug metabolism research, and forensic toxicology. The incorporation of deuterium atoms provides a reliable tool for mass spectrometry-based assays, ensuring accurate and reproducible results.

Application

• Internal Standard for LC-MS/MS Analysis: Serves as a critical component in the quantitative bioanalysis of Zopiclone in biological matrices such as plasma, serum, and urine.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used to trace and quantify the parent drug and its metabolites, facilitating studies on absorption, distribution, metabolism, and excretion (ADME).
• Forensic and Clinical Toxicology: Enables accurate detection and confirmation of Zopiclone levels in forensic investigations and clinical overdose cases.
• Pharmaceutical Quality Control: Acts as a reference standard for method development and validation in the quality control of Zopiclone active pharmaceutical ingredients (APIs) and finished dosage forms.
• Stable Isotope Labeling Research: Used in academic and industrial research to investigate chemical and metabolic pathways using isotope effects.

Basic Information

Product Name	Zopiclone-D8
CAS No.	1215518-83-4
Molecular Formula	C17H9D8ClN6O3
Molecular Weight	395.85 g/mol
Synonyms	6-(5-Chloro-2-pyridinyl)-6,7-dihydro-7-oxo-5H-pyrrolo[3,4-b]pyrazin-5-yl-4-methyl-1-piperazinecarboxylate-d8; Deuterated Zopiclone; Zopiclone (phenyl-d5, methyl-d3); Zopiclone-d8; (RS)-6-(5-Chloro-2-pyridyl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl-4-methylpiperazine-1-carboxylate-d8
EINECS	Contact for details

Quality Control

Our Zopiclone-D8 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR, HPLC, and MS, to confirm isotopic purity, chemical purity, and structural identity. We provide a comprehensive Certificate of Analysis (COA) with each shipment, detailing batch-specific results. Our quality commitment ensures the material meets the stringent requirements for use as a certified reference standard in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98 atom % D
Chemical Purity	≥ 95%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.