Description

Difluoro(5-Methylpyridin-2-Yl)Acetic Acid (CAS NO 1215421-88-7) is a high-value fluorinated pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both a difluoroacetic acid moiety and a methyl-substituted pyridine ring, makes it an essential intermediate for introducing specific fluorine-containing pharmacophores. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients with enhanced properties.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting metabolic diseases, CNS disorders, and oncology.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and insecticides, where the difluoroacetate group can improve bioavailability and environmental stability.
• Ligand and Catalyst Precursor: Serves as a starting material for synthesizing specialized ligands in coordination chemistry and catalysis, useful in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the development of novel fluorinated polymers, liquid crystals, or electronic materials that require specific pyridine-based architectures.
• Chemical Biology Probe Development: Utilized as a scaffold for creating molecular probes and tags used in biochemical assays and diagnostic research due to its modifiable acid and aromatic groups.

Basic Information

Product Name	Difluoro(5-Methylpyridin-2-Yl)Acetic Acid
CAS No.	1215421-88-7
Molecular Formula	C8H7F2NO2
Molecular Weight	187.14 g/mol
Synonyms	2-(5-Methylpyridin-2-yl)-2,2-difluoroacetic acid; (5-Methyl-2-pyridyl)difluoroacetic Acid; Difluoro(5-methyl-2-pyridinyl)acetic Acid; 2,2-Difluoro-2-(5-methylpyridin-2-yl)acetic acid; α,α-Difluoro-5-methyl-2-pyridineacetic acid
EINECS	Contact for details

Quality Control

Every batch of Difluoro(5-Methylpyridin-2-Yl)Acetic Acid is produced under strict quality management systems. We employ advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment, ensuring full traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.