Description

7-Hydroxy Coumarin-D5 is a deuterium-labeled analog of the naturally occurring compound umbelliferone, serving as a critical internal standard for quantitative analytical methods. This high-purity, isotopically labeled compound is essential for ensuring accuracy and precision in mass spectrometry-based analyses by correcting for instrument variability and sample preparation losses. It is primarily utilized by researchers and quality control laboratories in the pharmaceutical, agrochemical, and environmental testing industries where precise metabolite quantification is required.

Application

• Internal Standard for LC-MS/MS: Essential for the accurate quantification of 7-hydroxycoumarin and its metabolites in pharmacokinetic and drug metabolism studies.
• Biomarker Research: Used in tracer studies to investigate enzymatic activities, particularly those of cytochrome P450 enzymes like CYP2A6, in biomedical research.
• Environmental Analysis: Employed as a reference standard in the detection and measurement of coumarin derivatives in environmental samples.
• Pharmaceutical Development: Critical for method development and validation in bioanalytical assays during drug discovery and development stages.
• Food and Flavor Safety Testing: Supports analytical methods monitoring coumarin levels in food products to ensure regulatory compliance.
• Metabolomics: Serves as a stable isotope-labeled standard in high-throughput metabolomic profiling to ensure data reliability.

Basic Information

Product Name	7-Hydroxy Coumarin-D5
CAS No.	1215373-23-1
Molecular Formula	C9H3D5O3
Molecular Weight	167.18 g/mol
Synonyms	Umbelliferone-D5; 7-Hydroxy-2H-1-benzopyran-2-one-D5; 7-Hydroxy-2H-chromen-2-one-D5; 7-Hydroxycoumarin (phenyl-D5); Skimmetin-D5; Hydrangin-D5
EINECS	Contact for details

Quality Control

Every batch of 7-Hydroxy Coumarin-D5 is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and isotopic enrichment meet the highest standards. Our quality assurance protocol includes comprehensive characterization by NMR, HPLC, and mass spectrometry. A detailed Certificate of Analysis (COA) providing batch-specific data for purity, isotopic purity (D-enrichment), and residual solvent content is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.