Description

7-(4-Bromobutoxy)-3,4-Dihydroquinolin-2-One-D8 is a deuterated derivative of a quinolinone-based organic compound, serving as a crucial stable isotope-labeled intermediate. This compound matters for enabling advanced research and development in pharmacokinetics, metabolic studies, and analytical method validation, where precise tracing is essential. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions focused on developing and characterizing novel therapeutic agents.

Application

• Pharmaceutical Reference Standard: Used as an internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) for the quantitative analysis of its non-deuterated counterpart.
• Metabolic Pathway Tracing: Employed in drug metabolism and pharmacokinetics (DMPK) studies to investigate the absorption, distribution, metabolism, and excretion (ADME) profiles of lead compounds.
• Isotope Dilution Mass Spectrometry (IDMS): A critical component in high-precision quantitative assays to ensure accuracy and compensate for matrix effects or instrument variability.
• Biochemical Research: Utilized as a tracer in mechanistic studies to understand enzyme interactions and biological pathways without interference from the endogenous compound.
• Process Chemistry & Impurity Profiling: Aids in the identification and quantification of process-related impurities and degradants during active pharmaceutical ingredient (API) development and manufacturing.

Basic Information

Product Name	7-(4-Bromobutoxy)-3,4-Dihydroquinolin-2-One-D8
CAS No.	1215336-46-1
Molecular Formula	C13H9D8BrNO2
Molecular Weight	Contact for details
Synonyms	7-(4-Bromobutoxy)-3,4-dihydro-2(1H)-quinolinone-d8; 7-(4-Bromobutoxy)-1,2,3,4-tetrahydroquinolin-2-one-d8; 2-Oxo-1,2,3,4-tetrahydroquinolin-7-yl 4-bromobutyl ether-d8; Deuterated 7-(4-Bromobutoxy)carbostyril; [D8]-7-(4-Bromobutoxy)-3,4-dihydroquinolin-2(1H)-one; 7-(4-Bromobutoxy)-3,4-dihydro-2(1H)-quinolinone (deuterated, D8); Stable Isotope Labeled 7-(4-Bromobutoxy)quinolinone
EINECS	Contact for details

Quality Control

Our deuterated compounds are produced under strict quality protocols to ensure isotopic purity and chemical integrity. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR and HPLC-MS, to confirm deuterium incorporation and chemical purity. Certificates of Analysis (COA) detailing isotopic enrichment (typically ≥98 atom % D), chemical purity (by HPLC), and identity confirmation are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under an inert atmosphere at lower temperatures (-20°C) to maximize stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95%
Isotopic Purity (NMR/MS)	≥98 atom % D
Chemical Purity (by HPLC)	≥95%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.