Description

Sirt6-In-1 CAS NO 1214468-35-5 is a high-purity, small molecule inhibitor specifically designed to target and modulate the activity of Sirtuin 6 (SIRT6), a key enzyme involved in cellular metabolism, DNA repair, and aging processes. This compound is critical for researchers and developers in the life sciences sector, providing a precise tool for investigating epigenetic regulation and metabolic pathways. It is primarily utilized in pharmaceutical R&D, academic research, and biotechnology for target validation, mechanism-of-action studies, and the development of novel therapeutic agents.

Application

• Pharmaceutical Research & Development: Used as a reference standard and active tool compound for studying SIRT6 biology and validating drug targets in areas like oncology, metabolic disorders, and neurodegenerative diseases.
• Academic & Preclinical Studies: Essential for in vitro and in vivo research to elucidate the role of SIRT6 in aging, inflammation, and genome stability.
• Biochemical Assay Development: Serves as a key inhibitor in high-throughput screening (HTS) campaigns and enzymatic assays to discover and characterize new SIRT6 modulators.
• Epigenetics and Cell Signaling Research: A vital reagent for investigating histone deacetylation, gene expression regulation, and related cellular signaling pathways.
• Biotechnology and CRO Services: Supplied to contract research organizations and biotech companies for client projects focused on sirtuin-related therapeutic discovery.

Basic Information

Product Name	Sirt6-In-1
CAS No.	1214468-35-5
Molecular Formula	C₂₀H₂₀N₄O₂S
Molecular Weight	380.46 g/mol
Synonyms	SIRT6-IN-1; Sirt6 Inhibitor 1; 2-((4-Methoxyphenyl)sulfonyl)-N-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-4-amine; 2-[(4-Methoxyphenyl)sulfonyl]-N-(5-methyl-1,3,4-thiadiazol-2-yl)quinazolin-4-amine; Quinazoline, 2-[(4-methoxyphenyl)sulfonyl]-N-(5-methyl-1,3,4-thiadiazol-2-yl)-4-amino-; Sirtuin 6 Inhibitor
EINECS	Contact for details

Quality Control

Our Sirt6-In-1 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity suitable for research applications. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing desiccated at -20°C. Handle and store in accordance with good laboratory practices.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.