Description

1-(Difluoromethyl)-3,5-Bis(Trifluoromethyl)Benzene is a highly fluorinated aromatic building block of significant interest in advanced organic synthesis. Its unique structure, featuring multiple fluorine atoms, is engineered to impart enhanced metabolic stability, lipophilicity, and bioavailability to target molecules. This compound is primarily sought by R&D and process development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS, oncology, and anti-inflammatory diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms improve compound efficacy and environmental persistence.
• Material Science Precursor: Serves as a monomer or building block for specialty polymers, liquid crystals, and electronic materials requiring high thermal and chemical stability.
• Fluorine Chemistry Research: An essential reagent for exploring new fluorination methodologies and studying structure-activity relationships (SAR) in fluorine-containing compounds.
• Positron Emission Tomography (PET) Tracer Development: Potential use as a precursor for radiolabeling with fluorine-18 (18F) for diagnostic imaging agents.

Basic Information

Product Name	1-(Difluoromethyl)-3,5-Bis(Trifluoromethyl)Benzene
CAS No.	1214388-66-5
Molecular Formula	C9H4F8
Molecular Weight	264.12 g/mol
Synonyms	α,α-Difluoro-3,5-bis(trifluoromethyl)toluene; 3,5-Bis(trifluoromethyl)benzylidene difluoride; 1-(Difluoromethyl)-3,5-bis(trifluoromethyl)benzene; Benzene, 1-(difluoromethyl)-3,5-bis(trifluoromethyl)-; 3,5-Di(trifluoromethyl)benzyl Difluoride
EINECS	Contact for details

Quality Control

Our production of 1-(Difluoromethyl)-3,5-Bis(Trifluoromethyl)Benzene adheres to stringent internal quality standards to ensure batch-to-batch consistency and reliability for critical R&D and scale-up processes. Each lot is characterized using advanced analytical techniques including GC, HPLC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and reactive metals. The container should be kept tightly sealed to prevent moisture ingress and potential decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.