Description

6-(Difluoromethoxy)-3-Fluoropyridine-2-Carboxylic Acid is a high-value fluorinated pyridine derivative, serving as a critical building block in modern synthetic chemistry. Its unique structure, featuring both difluoromethoxy and carboxylic acid functional groups, makes it indispensable for introducing specific physicochemical properties into target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the fluorinated moiety enhances biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a versatile scaffold for creating novel ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of specialty polymers and advanced organic electronic materials due to its electron-withdrawing characteristics.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	6-(Difluoromethoxy)-3-Fluoropyridine-2-Carboxylic Acid
CAS No.	1214386-58-9
Molecular Formula	C7H4F3NO3
Molecular Weight	207.11 g/mol
Synonyms	3-Fluoro-6-(difluoromethoxy)picolinic acid; 2-Pyridinecarboxylic acid, 6-(difluoromethoxy)-3-fluoro-; 6-(Difluoromethoxy)-3-fluoro-2-pyridinecarboxylic acid; 3-Fluoro-6-(difluoromethoxy)pyridine-2-carboxylic acid; DFM-F-Py-2-COOH; (3-Fluoro-6-(difluoromethoxy)pyridin-2-yl)methanol (oxidized form)
EINECS	Contact for details

Quality Control

Every batch of 6-(Difluoromethoxy)-3-Fluoropyridine-2-Carboxylic Acid is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the stringent requirements for advanced synthetic applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles as determined by HPLC, NMR, and MS.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.