Description

1-(Trifluoromethyl)-3-Methoxy-5-Methylbenzene is a high-purity fluorinated aromatic building block of significant interest in advanced organic synthesis. Its value lies in the unique combination of the electron-withdrawing trifluoromethyl group and the methoxy substituent, which enables precise modulation of electronic and steric properties in target molecules. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in areas requiring fluorinated motifs for enhanced metabolic stability, bioavailability, and lipophilicity.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group often contributes to improved biological activity and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs), influencing charge transport and emission properties.
• Polymer & Specialty Chemistry: Incorporated into specialty monomers and polymers to impart specific chemical resistance, thermal stability, or surface properties to high-performance materials.
• Cross-Coupling Reactions: An effective substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) for constructing complex biaryl and heteroaryl systems.
• Chemical Research & Development: A versatile reagent in academic and industrial R&D for exploring new synthetic methodologies and creating compound libraries for screening.

Basic Information

Product Name	1-(Trifluoromethyl)-3-Methoxy-5-Methylbenzene
CAS No.	1214385-12-2
Molecular Formula	C9H9F3O
Molecular Weight	190.16 g/mol
Synonyms	3-Methoxy-5-methylbenzotrifluoride; 5-Methyl-3-(trifluoromethyl)anisole; 3-Methoxy-α,α,α-trifluoro-5-methyltoluene; 1-Methoxy-3-methyl-5-(trifluoromethyl)benzene; m-Methoxy-m-methylbenzotrifluoride; 3-Methyl-5-(trifluoromethyl)anisole; 5-(Trifluoromethyl)-3-methoxytoluene
EINECS	Contact for details

Quality Control

Our 1-(Trifluoromethyl)-3-Methoxy-5-Methylbenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and fluorides. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.