Description

2-(Difluoromethoxy)-1-Fluoro-4-Methyl-Benzene is a high-value fluorinated aromatic building block, prized for its unique difluoromethoxy and fluoro substituents which impart enhanced metabolic stability and lipophilicity to target molecules. This compound is essential for research and development in advanced organic synthesis, particularly for creating novel compounds with specific biological or material properties. It is primarily sought by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing next-generation agrochemicals, pharmaceuticals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of active pharmaceutical ingredients (APIs), especially for introducing the metabolically stable difluoromethoxy group.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides where fluorine atoms improve efficacy and environmental profile.
• Liquid Crystal & OLED Material Research: Serves as a precursor in the development of fluorinated organic semiconductors and liquid crystal compounds for electronic displays.
• Fluorinated Polymer Modification: Employed to introduce fluorine-containing side chains into polymers to alter surface properties, chemical resistance, and thermal stability.
• Organic Synthesis Building Block: Utilized in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution to construct complex, fluorinated molecular architectures.
• Positron Emission Tomography (PET) Tracer Development: Potential use as a precursor for synthesizing fluorine-18 labeled radiotracers for medical imaging.

Basic Information

Product Name	2-(Difluoromethoxy)-1-Fluoro-4-Methyl-Benzene
CAS No.	1214382-97-4
Molecular Formula	C8H7F3O
Molecular Weight	176.14 g/mol
Synonyms	1-Fluoro-4-methyl-2-(difluoromethoxy)benzene; 2-(Difluoromethoxy)-1-fluoro-4-methylbenzene; 4-Methyl-2-(difluoromethoxy)fluorobenzene; o-Difluoromethoxy-4-fluoro-1-methylbenzene; Benzene, 2-(difluoromethoxy)-1-fluoro-4-methyl-; 1-Fluoro-2-(difluoromethoxy)-4-methylbenzene; 4-Fluoro-3-methylphenyl difluoromethyl ether
EINECS	Contact for details

Quality Control

Every batch of 2-(Difluoromethoxy)-1-Fluoro-4-Methyl-Benzene is produced and tested under a strict quality management system. We employ advanced analytical techniques including GC, HPLC, NMR, and GC-MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical properties is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and bases. Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC)	≥ 97.0%
Purity (HPLC)	≥ 96.5%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.