Description

4-(Difluoromethyl)-1,2-Difluorobenzene is a specialized fluorinated aromatic building block of significant interest in advanced chemical synthesis. This compound matters for its role as a key intermediate in the development of pharmaceuticals and agrochemicals, where its unique difluoromethyl and difluoro substitution pattern can dramatically alter the biological activity and metabolic stability of target molecules. Industries such as pharmaceutical R&D, agrochemical manufacturing, and material science require this high-purity intermediate for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of drugs targeting central nervous system (CNS) disorders, anti-infectives, and oncology therapeutics.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and insecticides, where fluorine incorporation enhances lipophilicity and environmental stability.
• Material Science Precursor: Serves as a monomer or modifier in the synthesis of specialty polymers, liquid crystals, and advanced organic electronic materials.
• Organic Synthesis Reagent: Employed in cross-coupling reactions, such as Suzuki or Negishi couplings, to introduce the difluoromethylbenzene moiety into complex molecular architectures.
• Fluorine Chemistry Research: A valuable compound for academic and industrial research exploring new fluorination methodologies and the effects of fluorine on molecular properties.

Basic Information

Item	Detail
Product Name	4-(Difluoromethyl)-1,2-Difluorobenzene
CAS No.	1214379-64-2
Molecular Formula	C7H4F4
Molecular Weight	164.10 g/mol
Synonyms	1,2-Difluoro-4-(difluoromethyl)benzene; α,α,3,4-Tetrafluorotoluene; 3,4-Difluoro-α,α-difluorotoluene; 4-(Difluoromethyl)-o-difluorobenzene; Benzene, 1,2-difluoro-4-(difluoromethyl)-; Tetrafluoromethylbenzene derivative
EINECS	Contact for details

Quality Control

Our 4-(Difluoromethyl)-1,2-Difluorobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency suitable for sensitive synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and organic solvents. The container must be kept tightly closed in a dry and well-ventilated place.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.