Description

2-(Difluoromethoxy)-3-Fluoropyridine is a high-value fluorinated pyridine derivative, a key building block in modern synthetic chemistry. Its unique difluoromethoxy and fluoro substituents make it a critical intermediate for introducing fluorine motifs into complex molecules, enhancing their metabolic stability and lipophilicity. This compound is essential for research and development in the pharmaceutical and agrochemical industries, where it is used to create novel active ingredients.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors, antiviral agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms improve biological activity and environmental persistence.
• Material Science Precursor: Serves as a specialty monomer or ligand precursor in the development of advanced polymers, liquid crystals, and electronic materials.
• Organic Synthesis Reagent: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution to construct complex heterocyclic systems.
• Fluorine Chemistry Research: A valuable substrate for studying new fluorination methodologies and the effects of fluorine substitution on molecular properties.

Basic Information

Product Name	2-(Difluoromethoxy)-3-Fluoropyridine
CAS No.	1214377-43-1
Molecular Formula	C6H4F3NO
Molecular Weight	163.10 g/mol
Synonyms	3-Fluoro-2-(difluoromethoxy)pyridine; 2-(Difluoromethoxy)-3-fluoropyridine; 3-Fluoro-2-difluoromethoxypyridine; Pyridine, 3-fluoro-2-(difluoromethoxy)-; 1214377-43-1; FC-03 (Potential research code)
EINECS	Contact for details

Quality Control

Every batch of 2-(Difluoromethoxy)-3-Fluoropyridine is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the precise requirements for advanced synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are supplied with each shipment. Our quality protocols are designed to support cGMP and ISO-guided production for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its fluoride/strong alkali reactivity profile and high volatility, keep away from heat, sparks, and incompatible materials. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.