Description

5-Bromo-2-Methoxy-3-(Trifluoromethyl)Pyridine is a high-value, multi-functional heterocyclic building block characterized by its bromine and trifluoromethyl substituents. This compound is essential for introducing specific steric and electronic properties into target molecules, enabling the development of advanced materials and active ingredients. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for use in medicinal chemistry, pesticide discovery, and the synthesis of functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and anti-inflammatory pathways.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, where the pyridine core and halogenated motifs contribute to biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for constructing specialized ligands in transition metal catalysis and organocatalysis, facilitating challenging synthetic transformations.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as charge-transport layers or emissive compounds for OLEDs, due to its electron-deficient aromatic system.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form complex biaryl structures.
• Chemical Biology Probes: Utilized as a building block for fluorescent tags, photoaffinity labels, and other molecular probes used in biochemical assay development and diagnostic research.

Basic Information

Product Name	5-Bromo-2-Methoxy-3-(Trifluoromethyl)Pyridine
CAS No.	1214377-42-0
Molecular Formula	C8H5BrF3NO
Molecular Weight	256.03 g/mol
Synonyms	3-(Trifluoromethyl)-5-bromo-2-methoxypyridine; 2-Methoxy-5-bromo-3-(trifluoromethyl)pyridine; 5-Bromo-2-methoxy-3-trifluoromethylpyridine; 5-Bromo-2-methoxy-α,α,α-trifluoro-3-picoline; Pyridine, 5-bromo-2-methoxy-3-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-Methoxy-3-(Trifluoromethyl)Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP, ISO, and other relevant regulatory frameworks for research and commercial use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.